Relapse, even following an extended period of withdrawal, is a major challenge in substance abuse management. Delayed neurobiological effects of the drug during prolonged withdrawal likely contribute to sustained vulnerability to relapse. Stress is a major trigger of relapse, and the hippocampus regulates the magnitude and duration of stress responses. Recent work has implicated hippocampal pla...

nineteen bread wheat genotypes were selected to examine the effect of glycine betaine (gb, 100 mm) on various photosynthetic gas exchange parameters under drought stress and to study the relationship of these parameters with non-enzymatic antioxidants. drought stress caused a significant decline in net co2 assimilation rate (pn), stomatal conductance (gs), intercellular co2 concentration (ci) a...

Four hundred and fourteen healthy infants born in the Department of Obstetrics and Gynaecology were investigated. In no case was pregnancy complicated by toxaemia. All infants were delivered spontaneously without complications in occipitoanterior presentation and they showed no signs of asphyxia. In order to obtain reliable information on the duration of gestation, the dates on menstrual age we...

The Ozone Monitoring Instrument (OMI) onboard the NASA EOS Aura spacecraft is a nadir viewing spectrometer that measures solar reflected and backscattered light in a selected range of the ultraviolet and visible spectrum. The instrument has a 2600 km wide viewing swath and it is capable of daily, global contiguous mapping. We have developed and implemented a surface ultraviolet irradiance algor...

The mechanical stress imposed on the lungs during breathing is an important modulator of airway responsiveness in vivo. Our recent study demonstrated that continuous positive airway pressure applied to the lungs of nonanesthetized, tracheotomized rabbits for 4 days decreased lower respiratory system responsiveness to challenge with ACh (Xue Z, Zhang L, Ramchandani R, Liu Y, Antony VB, Gunst SJ,...

Unfolded proteins and other conditions affecting endoplasmic reticulum (ER) homeostasis cause ER stress. The cell reacts to ER stress by activation of the unfolded protein response (UPR), which induces profound changes in cellular metabolism including general translation attenuation, transcriptional upregulation of molecular chaperone genes, and activation of ER-associated degradation. However,...

Stress fractures of the proximal tibia metaphysis are rare in the elderly. We present a case of a 65-year old male who developed sequential proximal tibia stress fractures associated with prolonged usage of methotrexate and prednisolone within a span of 18 months. Magnetic Resonance Imaging revealed an incomplete stress fracture involving the medial proximal tibial region. The patient was treat...

'wake-up' to the situation at hand. When the threat disappears, the bodv chemistry returns to normal. But in the case of prolonged fear, whether caused bv an emotional stress or a physical threat, changes in body chemistry may be so frequent and acute that thev may threaten our health. For example, soldiers subjected to prolonged fighting?and thus prolonged fear and anxiety?underwent marked cha...

Proinflammatory cytokine interleukin-1 (IL-1) produced during psychological and immunological stress, plays a significant role in the neuroendocrine and stress responses. Brain IL-1 is an important mediator in stress-induced stimulation of the limbic-hypothalamic-pituitary-adrenal axis and secretion of ACTH and corticosterone. This review aims to describe some signaling pathways between the lim...

To the Editor In a randomized clinical trial, Dr Foa and colleagues examined prolonged exposure psychotherapy for co-occurring posttraumatic stress disorder (PTSD) and alcohol dependence. Prolonged exposure therapy was studied in relation to supportive counseling, use of naltrexone, and a pill placebo. The article provides an example of how the same findings can be interpreted quite differently...