We introduce intergrid operator recently developed for the cell centered finite difference multigrid on rectangular grids. The main idea of operator construction is based on flux continuity and certain kind of interpolation. This operator works well for solving diffusion equations both with discontinuous coefficient and with smooth coefficient. We disscuss on the construction of prolongation op...

A type of prolongation structure for several general systems is discussed. They are based on a set of one forms for which the underlying structure group of the integrability condition corresponds to the Lie algebra of SL(2, R), O(3), and SU(3). Each will be considered in turn and the latter two systems represent larger 3 × 3 cases. This geometric approach is applied to all of the three of these...

Results: 1646 cases of ventricular arrhythmia or cardiac arrest and 379 cases of QTc prolongation or torsade de pointes were associated with methadone. Monthly reports of QTc prolongation or torsade de pointes increased from a mean of 0.3 (95% CI, 0.1 to 0.5) before the 2002 publication to a mean of 3.5 (CI, 2.5 to 4.8) after it. After 2000, methadone was the second-most common primary suspect ...

Introduction Life-threatening arrhytmias, including torsades de pointes and ventricular fibrillation, may be induced by corrected QT (QTc) interval prolongation. Several antimicrobial drugs have been associated with QTc interval prolongation [1,2]. Favipiravir is an inhibitor of the RNA-dependent RNA polymerase of many RNA viruses, including influenza viruses, arenaviruses, phleboviruses, hanta...

Antipsychotic drugs have a central role in treating schizophrenia, but they are associated with a variety of side effects. One of the most dangerous adverse effects of these agents is prolongation of the heart rate-corrected QT interval (QTc). QTc prolongation is associated with the occurrence of torsades de pointes, a polymorphic ventricular tachycardia which may precipitate lethal ventricular...

QT prolongation is a serious adverse drug effect, which is associated with an increased risk of Torsade de pointes and sudden death. Many drugs, including both cardiac and non-cardiac drugs, have been reported to cause prolongation of QT interval. Although meperidine has not been considered proarrhythmic, we present a unique case of a 16-year-old boy without an underlying cardiac disease, who d...

Drug-induced QT interval prolongation is one of the most common reasons for the withdrawal of drugs from the market. In the past decade, at least nine drugs, i.e. terfenadine, astemizole, grepafloxacin, terodiline, droperidol, lidoflazine, sertindole, levomethadyl and cisapride, have been removed from the market or their use has been severely restricted because of drug-induced QT interval prolo...

The mechanisms of the inotropic effect of mitoxantrone (MTO), a synthetic dihydroxyanthracenedione derivative with antineoplastic activity, was investigated in guinea pig ventricular myocytes using whole-cell patch-clamp methods combined with fura-2 fluorescence and cell-edge tracking techniques. In right ventricular papillary muscles, 30 microM MTO increased isometric force of contraction as w...

AIM To determine the prevalence of QT prolongation in a large series of end stage liver disease (ESLD) patients and its association to clinical variables and mortality. METHODS The QT interval was measured and corrected for heart rate for each patient, with a prolonged QT cutoff defined as QT > 450 ms for males and QT > 470 ms for females. Multiple clinical variables were evaluated including ...

BACKGROUND To conduct a systematic review and meta-analysis to assess the overall incidence and risk of interstitial lung disease (ILD) and QTc prolongation associated with anaplastic lymphoma kinase (ALK)-tyrosine kinase inhibitors (-TKIs) in non-small-cell lung cancer (NSCLC) patients. RESULTS A total of 1,770 patients from 8 clinical trials were included. The incidences of high-grade ILD a...