objectives: this study investigated the possible synergistic effect of simultaneous treatment of bone morphogenic protein (bmp)-4 as a chemical stimulator and static magnetic field (smf) as a physical stimulator on viability percent and proliferation rate in rat bone marrow stem cells. methods: passage 5 cells were trypsinized, and a cell suspension prepared after which the cells were counted ...

in recent years, considerable advances have been made in the field of regenerative medicine. unlikeembryonic stem cells, which pose the problems of ethical concerns and cause severe immunological reactions as well as neoplasma formation after transplantation, umbilical cord blood is a primitive source ofmesenchymal stem cells that covers the benefits of both embryonic and adult stem cells. it h...

in addition to its antioxidant effect, vitamin e or α–tocopherol is suggested to enhance remyelination in the animal model of non-inflammatory demyelination. in this study, the possible proliferative effect of vitamin e on human- induced pluripotent stem cell-derived neural progenitors (hips-nps) and the underlying mechanisms were investigated in vitro. nps were induced from ips cells via 3 ste...

olea europaea l. commonly known as olive has been traditionally used for the prevention and treatment of many diseases since ancient times. olive has been reported to possess a broad spectrum of pharmacological properties. in the present study we investigated the activity of aqueous extract of olea europaea l. fruit at various concentrations on a2780, a172 and hfff2 cell lines proliferation by ...

Tamoxifen is routinely used for treatment of Estrogen-positive breast carcinoma. Approximately, 50% of patients with metastatic cancer will develop resistance to Tamoxifen. In this research, Tamoxifen was combined with the anti-cancer compound Curcumin. Diblock nanopolymer was used to package the new formulation of Curcumin and Tamoxifen. Anti-cancer efficacy of the obtained compound was evalua...

background: as the use of mobile phones is increasing, public concern about the harmful effects of radiation emitted by these devices is also growing. in addition, protection questions and biological effects are among growing concerns which have remained largely unanswered. stem cells are useful models to assess the effects of radiofrequency electromagnetic fields (rf-emf) on other cell lines. ...

the present study was designed to investigate the immunomodulatory activity of the ethanolic extract of tinospora cordifolia (family: menispermaceae)stem (climbing shrub, mango plant) at cellular level. for antioxidant study, the liver mitochondria were separated and the concentration of enzymes like lipid peroxidation (lpo), reduced glutathione (gsh), catalase (cat) and superoxide dismutase (s...

conclusions according to our results, silymarin injection caused significant differentiation of mscs to neurons and neuroglia that could be a promising approach for treating a variety of brain injuries. results expression of cd29 and cd90 markers that are characteristic of bmmscs were confirmed by flow cytometry experiments. the data demonstrated that proliferation and number of progenitor cell...

objective(s) some investigation has indicated that adipose-derived stem cells possess different surface epitopes and differentiation potential according to the localization of fat pad from which the cells were derived. in the present study proliferation capacity and aging of such cells were explored. materials and methods adherent cells were isolated from the collagenase digests of adipose tiss...