Building on the review by Goldner et al., I argue that the first research tasks for disability management in Canada should be to articulate conceptual models; define promising disability management interventions and characterize the current longitudinal health and labour market trajectories of Canadians disabled by mental conditions. Research should next emphasize pilot studies of novel interve...

The preclinical research process is a cycle of idea generation, experimentation, and reporting of results. The biomedical research community relies on the reproducibility of published discoveries to create new lines of research and to translate research findings into therapeutic applications. Since 2012, when scientists from Amgen reported that they were able to reproduce only 6 of 53 "landmark...

Dear Sir: I read with great interest the article by Ng and others entitled " Assessing the contribution of malaria vector control and other maternal and child health interventions in reducing all-cause under-five mortality in Zambia. " 1 Considering that malaria was possibly not the most important cause of death in children under 5 years of age (U5) in Zambia, and that maternal and child health...

Ming-Sound Tsao, MD, FRCPC, is a Clinical Scientist in the Depart­ ment of Pathology, University Health Net work, and Department of Laboratory Medicine and Pathobiology, University of Toronto. Email: [email protected] INTRoDuCTIoN Lung cancer is the leading cause of cancer-related death worldwide among males, and the second leading cause among females. In 2008, it accounted for 13% (1.6 million)...

In this paper we review evidence from social, developmental, and evolutionary psychology to raise a common question: Are there priorities in how humans categorize their social world? Are some social groupings more prominent in childhood, and more resilient in adulthood than others? We review and compare evidence from each field, with a particular emphasis on exploring the relative robustness of...

Can 28 major national organizations that collectively influence every part of the health care system really make a difference? That was my question when I first received a report from the National Quality Forum (NQF) in Washington, DC.1 Readers of my previous P&T columns might recall that Americans spend more per capita on health care than any other industrialized country, yet our results in te...

Resolving connicts between default rules is a major subtask in performing default reasoning. A declarative way of controlling the resolution of connicts is to assign priorities to default rules, and to prevent connict resolution in ways that violate the priorities. This work extends Reiter's default logic with a priority mechanism that is based on lexicographic comparison. Given a default theor...

Acknowledgements We would like to thank the Nuffield Trust for giving us the opportunity to undertake this research work, with particular thanks to the Efficiency research programme steering group for their expert advice and guidance, and the reviewers for their very helpful and detailed comments. We would also like to thank those who helped develop and pilot the electronic survey. Finally, we ...

One-third of all human deaths are due to poverty-related causes, to malnutrition and to diseases that can be prevented or cured cheaply. Yet our politicians, academics, and mass media show little concern for how such poverty might be reduced. They are more interested in possible military interventions to stop human rights violations in developing countries, even though such interventions – at b...

Endometriosis is an estrogen-dependent disorder where endometrial tissue forms lesions outside the uterus. Endometriosis affects an estimated 10% of women in the reproductive-age group, rising to 30% to 50% in patients with infertility and/or pain, with significant impact on their physical, mental, and social well-being. There is no known cure, and most current medical treatments are not suitab...