BACKGROUND AND OBJECTIVE Additional loading doses and higher maintenance doses (MDs) have been used to overcome hyporesponsiveness of clopidogrel. We aimed to investigate whether genetic polymorphisms of two cytochromes (CYP2C19 and CYP2C9) and ABCB1 modify effect of such dose-adjustment strategy. MATERIALS AND METHODS We enrolled 118 patients undergoing elective or acute percutaneous coronar...

Since the virulence of a virus is usually multifactorial in both natural and experimental infections, it is of considerable interest to identify a situation in which a single genetic character controls virulence. Susceptibility or resistance to mouse hepatitis virus (MHV) 1 may be controlled by a single genetic character. In turn the genetic resistance of the Call mice to MHV Princeton strain (...

MicroRNA (miRNA) biogenesis is a highly regulated process in eukaryotic cells. Several mature miRNAs exhibit a tissue-specific pattern of expression without an apparent tissue-specific pattern for their corresponding primary transcripts. This discrepancy is suggestive of post-transcriptional regulation of miRNA abundance. Here, we demonstrate that the brain-enriched expression of miR-7, which i...

UNLABELLED aim: The aim of this study was the evaluation of the antitumor effect of two synthetic analogs of vitamin D, PRI-2191 and PRI-2205 in combined treatment with irinotecan or oxaliplatin on mouse (MC38) and human (HT-29) colon cancer cells. MATERIALS AND METHODS Mice bearing subcutaneous tumors were injected with vitamin D analogs and with irinotecan or oxaliplatin, according to vario...

Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. MicroRNA-34 (miR-34) gene plays a key role in altering the apoptotic cycle and pathways of downstream cells, and therefore influences carcinogenesis. In this case-control study, we assessed the role of the pri-miR-34b/c rs4938723 polymorphism in HCC risk. The pri-miR-34b/c polymorphic genotype was determined in ...

Synthetic analogs of vitamin D for potential use in differentiation therapy should selectively regulate genes necessary for differentiation without inducing any perturbations in calcium homeostasis. PRI-1906, an analog of vitamin D2, and PRI-2191, an analog of vitamin D3 bind nuclear vitamin D receptor (nVDR) with substantially lower affinity than 1,25-dihydroxyvitamin D3 (1,25-D3), but have hi...

From a simple idea to unite pension funds in their quest for responsible investment at its launch in April 2006, the United Nations supported Principles for Responsible Investment (PRI) have grown in just one decade into an initiative with more than 1,500 fee paying signatories. These signatories consist of asset owners (e.g. pension funds, charities), the asset managers that serve them and ser...

Multiple pulse repetition interval (multi-PRI) transmission is part of an adaptive signal transmission and processing algorithm being developed to aggressively combat range–velocity ambiguity in weather radars. In the past, operational use of multi-PRI pulse trains has been hampered due to the difficulty in clutter filtering. This paper presents finite impulse response clutter filter designs fo...

PURPOSE The decline in U.S. adolescent fertility has accelerated since 2007. Modeling fertility change using behavioral data can inform adolescent pregnancy prevention efforts. METHODS We used data on sexual activity and contraceptive use from National Surveys of Family Growth for young women 15-19 years of age, and contraceptive failure rates, to estimate a Pregnancy Risk Index (PRI) for the...

In this work, we present the Poroelastic Relaxation Indentation (PRI) testing approach for quantifying the mechanical and transport properties of thin layers of poly(ethylene glycol) hydrogels with thicknesses on the order of 200 mm. Specifically, PRI characterizes poroelastic relaxation in hydrogels by indenting the material at fixed depth and measuring the contact area-dependent load relaxati...