Background: In 2020, the pandemic caused by novel coronavirus infection has become one of most critical global health challenges during past century. The lack a vaccine, as effective way to control infection, prompted development large number preventive products scientific community. We have developed candidate vaccine (EpiVacCorona) against SARS-CoV-2 that is based on chemically synthesized pe...

vaccines against the hiv-1 virus offers the best hope for eliminating hiv-associated mortality. recombinant adenovector type 5 (rad5) vaccine is a potential candidate for preventive vaccine strategies. in this study, we evaluated the rad5 prime/protein boost strategy in a murine model. we used rad5 harboring single hiv-1 genes. these genes, including gag (p24) and exon1 of tat, were amplified f...

A combination of different types of vaccines usually induces enhanced immune responses in comparison to immunization with single vaccines. The highest efficacy of a heterologous prime-boost strategy is mostly achieved after priming with a DNA vaccine and boosting with a recombinant virus or a protein vaccine. The aim of this study was to determine whether the combination of a DNA and cellular v...

The worldwide quest for an AIDS vaccine represents an unprecedented scientific and human challenge for the 21st century. Preventive vaccines represent our only long-term hope to stop the epidemic. AIDS vaccines must be seen as the ultimate prevention tool that will complement the existing prevention strategies in place. The acceleration of vaccine development through the parallel exploration of...

OBJECTIVE To answer frequently asked questions surrounding the use of the new herpes zoster (HZ) vaccine. SOURCES OF INFORMATION Published results of clinical trials and other studies, recommendations from the Canadian National Advisory Committee on Immunization, and the US Advisory Committee on Immunization Practices; data were also obtained from the vaccine's Health Canada-approved product ...

Staphylococcus aureus is an invasive bacterial pathogen, and antibiotic resistance has impeded adequate control of infections caused by this microbe. Moreover, efforts to prevent human infections with single-component S. aureus vaccines have failed. In this study, we evaluated the protective efficacy in rats of vaccines containing both S. aureus capsular polysaccharides (CPs) and proteins. The ...


 Alternatives to stop chikungunya outbreaks are oriented vector control and developing a specific treatment preventive vaccine. Environmental mosquito bite prevention undoubtedly essential decrease the disease burden, but Aedes vectors continue expand geographically re-emerge. So, vaccination is proposed respond this etiology recognized as pressing need for affected countries. A mathemati...

AIM Routine vaccination is one of the most important preventive methods which is responsible for the decreasing trend of morbidity and mortality of vaccine preventable infectious diseases, their complications and sequelae. The impact of vaccination on declining trend of these diseases is well known and confirmed by a large number of epidemiological studies. In the Czech Republic, there is high ...

Background: Quick vaccine rollouts and compliance with preventive strategies are crucial for a country recovery from COVID-19, but hesitancy could prolong the pandemic need for physical distancing lockdowns. Aim of study: was to assess levels COVID-19 vaccine hesitancy, protective behaviors risk perception among university students in Alexandria. Study design: An online cross-sectional expl...

BACKGROUND Hemodialysis patient are at high risk for hepatitis B virus (HBV) infection. Although preventive vaccination is done routinely, the response to vaccination is low in this patient population. The aim of this study was to evaluate the effect of Levamizol, an enhancer of the immune responsiveness, on different routes of vaccination, i.e., intradermal (i.d.) versus intramuscular (i.m.), ...