BACKGROUND The Bradykinesia Akinesia Incoordination (BRAIN) test is a computer keyboard-tapping task that was developed for use in assessing the effect of symptomatic treatment on motor function in Parkinson's disease (PD). An online version has now been designed for use in a wider clinical context and the research setting. METHODS Validation of the online BRAIN test was undertaken in 58 pati...

This paper presents a method of integrating two contrasting sensor systems for studying human interaction with a mechanical system, using piano performance as the case study. Piano technique requires both precise small-scale motion of fingers on the key surfaces and planned large-scale movement of the hands and arms. Where studies of performance often focus on one of these scales in isolation, ...

The first part of this paper describes the editorial decisions that led to the publishing of The Skeptical Environmentalist (TSE) and the rejection of requests by critics that Cambridge should cease publication on the grounds of claims that it had not been peer-reviewed and that it would be abused by right wing political interests seeking justification for opposing new environmental regulation....

When performing sequences of actions, we constantly keep track of our current position in the sequence relative to the overall goal. The present study searched for neural representations of sequence progression in corticostriatal circuits. Neurons within the anterior cingulate cortex (ACC) and its target region in the dorsal striatum (DS) were recorded from simultaneously as rats performed diff...

BACKGROUND Decision-making studies show that response selection is influenced by the "effort cost" associated with response alternatives. These effort-cost calculations seem to be mediated by a distributed neural circuit including the anterior cingulate cortex and subcortical targets of dopamine neurons. On the basis of evidence of dysfunction in these systems in schizophrenia (SZ), we examined...

Tableting by direct compression (DC) is one of the simplest and most cost-effective drug manufacturing approaches. However, active pharmaceutical ingredients (APIs) excipients lack flow properties required to meet needs high-speed industrial tablet presses. Therefore, majority DC APIs are modified via processing/co-processing particle engineering techniques boost their properties. Spray drying ...

El interés por la traducción de este artículo, cuya autorización fue dada los autores, revista canadiense Meta [56(2), 318-335] y editorial Les Presses l’Université Montréal, surgió en el desarrollo del proyecto investigación Variación terminológica vertical horizontal español: hacia una descripción lingüística las unidades terminológicas desde corpus (VaTeHoVe), grupo Traducción Nuevas Tecnolo...

The Romance de doña Antonia Lisboa is one of the most prolific stories popularized news pamphlets in cordel literature Eighteenth century, present relevant printing presses that period. One them, undoubtedly, was Herederos Juan Jolis, Barcelona, whose copy ballad preserved at University Geneva. Its edition and study, its relationship with other similar rewritings will serve as an approach to su...