Non-steroidal antiinflammatory drugs presently are the most widely used drugs in medicine and their annual sales in the world are more than 6 billion dollars. Presently, more than 100 NSAIDs have been tested clinically and more than 50 are there in the world market. Nearly 35 million people are taking them on daily basis and FDA has ranked them the most frequent cause of adverse drug reactions....

This review outlines the history of bovine viral diarrhoea virus (BVDV) and the current situation in Australia and New Zealand. BVDV has been reported as present in cattle from both countries for close to 60 years. It rates as the second most economically significant disease afflicting cattle, and is highly prevalent and spread throughout the beef and dairy industries. While other cattle diseas...

BACKGROUND Metastatic insulinoma is a disease associated with a poor life expectancy. CASE REPORT The case of a presently 68 year old female with malignant, metastatic insulinoma is reported. Due to severe clinical symptoms surgical tumor mass reduction was conducted. Furthermore the patient underwent a chemotherapy using streptozotocine and fluorouracil. After two years without any symptoms,...

It is shown that the size effect predicted by dimensional analysis of fracture mechanics of failures due to progressive distributed microcracking agrees with the test data existing in the literature better than the presently used strength (ultimate load) criterion, which exhibits no size effect, and better than the linear i!lastic fracture mechanics criterion, which exhibits much too strong a s...

During the past decade, there has been a marked increase in the prevalence of community-acquired methicillin-resistant Staphylococcus aureus infection in the United States and elsewhere. The most common such infections are those involving the skin and skin structures. Although a number of these lesions (including small furuncles and abscesses) respond well to surgical incision and drainage, ora...

From a historical case of systemic envenoming and depression in Zambia details were kept. Presenting features fitted viper bite, warranting polyvalent antivenom intravenously. Applying presently used 'WHO guidelines for prevention clinical management snakebite Africa' (2010), indicate puff adder (Bitis arietans) bite similar treatment. Snakebite treatment need an update on psychological co-morb...

Climate change impacts and responses are presently observed in physical and ecological systems. Adaptation to these impacts is increasingly being observed in both physical and ecological systems as well as in human adjustments to resource availability and risk at different spatial and societal scales. We review the nature of adaptation and the implications of different spatial scales for these ...

X-ray crystallography shows the myosin cross-bridge to exist in two conformations, the beginning and end of the "power stroke." A long lever-arm undergoes a 60 degrees to 70 degrees rotation between the two states. This rotation is coupled with changes in the active site (OPEN to CLOSED) and phosphate release. Actin binding mediates the transition from CLOSED to OPEN. Kinetics shows that the bi...

The general performance of the Advanced Photon Source (APS) 352-MHz/1-MW continuous wave (CW) klystrons is discussed. The original seven-klystron inventory at the Advanced Photon Source has been in operation since 1995 with good results. Five tubes are presently in accelerator operation, with two tubes as spares. The overall performance of the tubes has been very good. Two tubes were removed fr...

Studies on the mode of action of the presently useful anti-leukemic drugs describe the metabolic features of leukemic lymphoblasts which serve as a basis for killing these cells selectively. Individually, these agents are inadequate in most cases to maintain prolonged remissions. The combined use, however, of drugs which act differently has the potentiality of greatly increasing the selectivity...