Radioprotective agents like selenium are used to reduce the damage caused by radiation in healthy tissues. The aim of this study was to evaluate the effect of sodium selenite on the development of the molars of offspring of rats irradiated during odontogenesis. Twenty pregnant rats were randomly divided into 4 groups: control, irradiated, selenium and selenium/irradiated. The selenium and selen...

BACKGROUND Using a rat model we have found that the bioflavonoid silymarin (SY) ameliorates some of the negative consequences of in utero exposure to ethanol (EtOH). In the current study our aim was to determine if laterality preference and corpus callosum development were altered in rat offspring whose mothers were provided with a concomitant administration of SY with EtOH throughout gestation...

INTRODUCTION The renal development of rats begins in intrauterine life, finishing by 15 days after birth. Diabetes and other diseases during pregnancy can cause systemic changes in the offspring. We evaluated the structural and functional renal alterations of the offspring from diabetic mothers. MATERIAL AND METHODS Pregnant rats were separated and 1, 7, 30 and 90 days-old (DO) pups were divi...

Valproate is a known human and animal teratogen that produces neural-tube defects. Valproate is also known to produce fetal death and a variety of fetal deformities. The present study considered the role of val pro ate as a behavioral teratogen in rats. Pregnant rats were administered saline or valproate, or simply handled at 10 days gestation and the offspring tested for a variety of behaviors...

1. Possible associations between maternal nutrition in pregnancy and non-communicable diseases of adulthood were assessed using a rat model. Rats were habituated to diets containing a range of protein levels (18, 12, 9 and 6% by weight), over a 14 day period, before mating. The low protein diets were maintained throughout pregnancy. Lactating mothers and their offspring were transferred to a st...

Use of antiepileptic drugs (AEDs) in pregnancy warrants various side effects and also deleterious effects on fetal development. The present study was carried out to assess the effects of prenatal exposure to lamotrigine (LTG) on postnatal development and behavioural alterations of offspring. Adult male and female Sprague Dawley rats weighing 150-180 g b. wt. were allowed to copulate and pregnan...

Obesity is generally associated with high intake of junk foods rich in energy, fat, sugar and salt combined with a dysfunctional control of appetite and lack of exercise. There is some evidence to suggest that appetite and body mass can be influenced by maternal food intake during the fetal and suckling life of an individual. However, the influence of a maternal junk food diet during pregnancy ...

Both maternal glucocorticoid administration and maternal dietary protein or food restriction in pregnancy cause fewer nephrons and hypertension in the adult offspring. The purpose of these studies was to determine the extent to which nutritional factors contribute to programming of offspring hypertension by maternal glucocorticoids. Pregnant rats were treated with dexamethasone (100 microg x kg...

background:the polysialylated neural cell adhesion molecule (psa-ncam) is expressed in developing brain. fetal brain damage is caused by different conditions such as seizure and hypoxia. the present study was designed to investigate the effect of maternal seizures on the number of psa-ncam positive cells in pup's hippocampus. methods: female wistar rats were divided into four groups: (a) k...

The exposure of the fetus/neonate to glycotoxins via placenta or breast milk, such as themethylglyoxal (MG), has been related short- and long-term disorders in its development.The aim this study was evaluate effects early methylglyoxal, duringthe lactation phase, on cardiac parameters at adulthood. All experimental procedures wereapproved by ethics committee animal use UFG (007/21). Eight pregn...