Noninvasive and convenient tests to assess pulmonary fibrosis and disease progression in interstitial lung diseases (ILDs) are currently unavailable. The extracellular matrix molecules, laminin (LN), type IV collagen (IVC), procollagen III N-terminal peptide (PIIINP), and hyaluronic acid (HA) are involved in ILD development and progression. This study aims to investigate the association of dise...

The world's worst chemical industrial disaster, which occurred at Bhopal on 2-3 December, 1984, resulted in considerable respiratory morbidity in the exposed population. Therefore, a study was planned to evaluate the relationship between lower respiratory tract inflammation, lung function and severity of exposure. Sixty patients exposed to methyl isocyanate and presenting with respiratory sympt...

Given the emerging physiological and clinical rationale for pharmacological lung-volume reduction, assessment of volume responses to bronchodilators is likely to be highly relevant in chronic obstructive pulmonary disease (COPD). The authors examined the magnitude of lung-volume reduction after acute bronchodilator treatment in patients with advanced emphysema. Eighty-four stable patients with ...

BACKGROUND Electronic medical records and insurance claims data from the Geisinger Health System were examined to assess the real-world healthcare costs of being overweight or obese at different glycemic stages, including normal glycemia, pre-diabetes (PreD), and type 2 diabetes (T2D). METHODS The medical history of the sample subjects was segmented into different glycemic stages via diagnosi...

BACKGROUND The prevalence of obesity is rising. Obesity can lead to cardiovascular and ventilatory complications through multiple mechanisms. Cardiac and pulmonary function in asymptomatic subjects and the effect of structured dietary programs on cardiac and pulmonary function is unclear. OBJECTIVE To determine lung and cardiac function in asymptomatic obese adults and to evaluate whether wei...

Abstract Introduction Interstitial lung disease (ILD) can manifest before the diagnosis of primary Sjögren's syndrome (pSS), however, underlying mechanisms remain unclear. The aim this study is to investigate characteristics lung‐onset pSS using chest high‐resolution computerized tomography (HRCT) and pulmonary function tests (PFTs). Methods data 102 patients with pSS‐ILD were retrospectively a...

ing Irrelevant Distinctions in Qualitative Simulationt Pierre Fouche( 1 ) & Benjamin Kuipers(2 ) (1 )Universitd de Technologie de Compibgne C.N .R.S . U.R.A. 817 B.P . 649 60206 Compiegne, France Email : fouche@ a frutc5l .bitnet (2)Department of Computer Sciences The University of Texas at Austin Austin TX 78712, USA Email : kuipers@ a cs .utexas.edu Abstract : One main problem in qualitative ...

Naphthyridine compounds are important, because they exhibit various biological activities including anticancer, antimicrobial, and anti-inflammatory activity. Some naphthyridines have antimitotic effects or demonstrate anticancer activity by inhibiting topoisomerase II. These compounds have been investigated as potential anticancer agents, and several compounds are now part of clinical trials. ...

This study aimed to determine the relationship between pulmonary function, respiratory muscle function and neurological function in multiple sclerosis (MS). Sixty patients (27 males and 33 females) aged 27-75 yrs (mean +/- SD 48 +/- 12 yrs) were prospectively studied. The Kurtzke Expanded Disability Status Scale (EDSS; range 0-10) score was 6.5 +/- 1.5; and the different Functional Systems Scor...