The process of invasion and metastasis during tumor progression is often reminiscent of cell migration events occurring during embryonic development. We hypothesized that genes controlling cellular changes in the Spemann organizer at gastrulation might be reactivated in tumors. The Goosecoid homeobox transcription factor is a known executer of cell migration from the Spemann organizer. We found...

The establishment of a left-right (LR) organizer in the form of the ventral node is an absolute prerequisite for patterning the tissues on contralateral sides of the body of the mouse embryo. The experimental findings to date are consistent with a mechanistic paradigm that the laterality information, which is generated in the ventral node, elicits asymmetric molecular activity and cellular beha...

in this study, we tried to examine the effectivences of advance organizer on boy students of high school 2nd grade in this experimental research design. our sample consisted of 184 second-grade high school students, including a control group and an expenimemal one, who were selected by using cluster sampling & randam mathing methods. a5.a pretest. a twenty-item test of geography, each of which ...

The Spemann organizer can be subdivided into head- and trunk-inducing tissues along the anteroposterior axis (Mangold, 1933. Naturwiisenschaften 43, 761-766; Spemann, 1931. Wilhelm Roux Arch. Entwicklungsmech. Org. 123, 389-517). Recent studies have suggested that head formation is brought about by repression of both Wnt and BMP signalling (Glinka et al., 1998. Nature 391, 357-362; Glinka et al...

Shaping the primordia during development relies on forces and mechanisms able to control cell segregation. In the imaginal discs of Drosophila the cellular populations that will give rise to the dorsal and ventral parts on the wing blade are segregated and do not intermingle. A cellular population that becomes specified by the boundary of the dorsal and ventral cellular domains, the so-called o...

The organizer is essential for dorsal-ventral (DV) patterning in vertebrates. Goosecoid (Gsc), a transcriptional repressor found in the organizer, elicits partial secondary axes when expressed ventrally in Xenopus, similar to an organizer transplant. Although gsc is expressed in all vertebrate organizers examined, knockout studies in mouse suggested that it is not required for DV patterning. Mo...

‘shield’, considered to be the fish equivalent of the Spemann organizer — and transplanted the cells into host embryos. The result was extra tails, consisting of donoras well as host-derived cells.Agathon et al. also showed that inactivating the Spemann organizer did not interfere with this ‘ectopic’ tail formation, implying that the two organizers are indeed independent. The authors concede, h...

A cytogenetic study was conducted on five species of the genus Pimelodus collected from various regions in Brazil: Pimelodus heraldoi, Pimelodus sp, Pimelodus argenteus, P. maculatus and P. mysteriosus. All the species had 2n=56 chromosomes. AgNOR was found in one pair of subtelocentric (ST) chromosomes with staining at the terminal position in all the five species. However, Pimelodus sp, P. he...

Wedding Organizer merupakan jasa yang membantu dalam persiapan dan pelaksanakan pesta pernikahan. Di sistem ini pengguna dapat memilih konsep pernikahan diinginakan seperti pelaminan dekorasi, baju pengantin, make up, dokumentasi, catering, hiburan. Platform aplikasi adalah android dengan menggunakan metode pengembangan prototyping. Hasil dari penelitian bisa melakukan pemesanan wedding organiz...

Using embryos transgenic for the TOP-GFP reporter, we show that the two zebrafish beta-catenins have different roles in the organizer and germ-ring regions of the embryo. beta-Catenin-activated transcription in the prospective organizer region specifically requires beta-catenin-2, whereas the ventrolateral domain of activated transcription is abolished only when both beta-catenins are inhibited...