In mature B lymphocytes, the zinc finger transcription factor early growth response 1 (Egr-1) is one of the many immediate-early genes induced upon B cell antigen receptor engagement. However, its role during earlier stages of lymphopoiesis has remained unclear. By examining bone marrow B cell subsets, we found Egr-1 transcripts in pro/pre-B and immature B lymphocytes, and Egr-1 protein in pro/...

The purpose of this paper is to provide a descriptive analysis of infant mortality patterns in a pre-industrial North American population, the Madawaska French of the upper St. John Valley. A synchronic approach was taken in examining a series of 320 infant deaths identified through family reconstitution. The infant mortality rate for the series is 132 per 1000, low compared to other pre-indust...

BACKGROUND Both maternal socio-economic status (SES) and growth measures are themselves interrelated and are also related to infant birthweight. The objective of this study is to compare the relative importance of such maternal measures as determinants of birthweight of female infants-the prospective mothers of the next generation. METHODS The study base was derived from a population-based mu...

OBJECTIVE To assess the cost effectiveness of adding universal hepatitis B vaccination in infancy or pre-adolescence to a policy of selective vaccination of at risk groups. DESIGN Costs of a selective policy and additional costs of universal vaccination policies were estimated from costs of vaccine delivery and published data on target populations. Additional years of life gained were calcula...

Introduction: Hamartomas is a neoplasms composed of mature tissue elements from the affected site with disproportion between their components. Although lingual hamartomas are traditionally infrequent in the head and neck, a significant number of case reports with this disorder in infancy are arising from the literature.   Case Report:</em...

Background Skin-to-skin care in the newborn intensive unit typically lasts for short periods of time and enhances breastfeeding, attachment, parental self-esteem. Heart rate variability (HRV) increases with gestational age is a measure maturation parasympathetic vs. sympathetic autonomic nervous system activity. HRV measurements may be useful capturing changes regulation response to skin-to-ski...

Transcripts contain introns that are usually removed from premessenger RNA (MRNA) in the process of pre-mRNA splicing. After splicing, the mature RNA is exported from the nucleus to the cytoplasm. The splicing and export processes are coupled. UAP56 protein, which is ubiquitously present in organisms from yeasts to humans, is a DExD/H-box family RNA helicase that is an essential splicing factor...

We examined whether placental DNA methylation of the glucocorticoid receptor gene, NR3C1 was associated with self-regulation and neuroendocrine responses to a social stressor in infancy. Placenta samples were obtained at birth and mothers and their infants (n = 128) participated in the still-face paradigm when infants were 5 months old. Infant self-regulation following the still-face episode wa...