نتایج جستجو برای: pr3 doped cofe2o4
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Elastase, but not PR3, induces proteinuria associated with loss of glomerular basement membrane (GBM) heparan sulphate after in vivo renal perfusion in rats. PR3 and elastase are cationic neutral serine proteinases present in the azurophilic granules of polymorphonuclear leucocytes. Release of these proteolytic enzymes along the glomerular capillary wall may induce glomerular injury. Here, we i...
Antineutrophil cytoplasmic autoantibody (ANCA) causes vascular injury that leads to small-vessel vasculitis. Patients with ANCA aberrantly express neutrophil granule-encoding genes, including 2 that encode autoantigens: proteinase 3 (PR3) and myeloperoxidase (MPO). To uncover a potential transcriptional regulatory mechanism for PR3 and MPO disrupted in patients with ANCA vasculitis, we examined...
Five-coordinate rhenium(I) hydride complexes of the type [Re(Br)(H)(NO)(PR3)2] (R = Cy 1a, iPr 1b) were reacted with terminal alkynes R1C�CH (R1 = Ph, SiEt3, H), yielding 18-electron �2alkyne adducts [Re(Br)(H)(NO)(PR3)2(�2-HC�CR1)] (R1 = Ph (R = Cy 2a, iPr 2b), SiEt3 (R = Cy 4a, iPr 4b), H (R = Cy 6a, iPr 6b)). Alkyne insertion into the Re−H bond led to the formation of rhenium(I) �1-vinyl der...
■ REFERENCES (1) Tizei, L. H. G.; Lin, Y.-C.; Mukai, M.; Sawada, H.; Lu, A.-Y.; Li, L.J.; Kimoto, K.; Suenaga, K. Exciton Mapping at subwavelength scales in two-dimensional materials. Phys. Rev. Lett. 2015, 114, 107601. (2) Sasaki, T.; Sawada, H.; Hosokawa, F.; Sato, Y.; Suenaga, K. Aberration-corrected STEM/TEM imaging at 15kV. Ultramicroscopy 2014, 145, 50−55. (3) Velaźquez, M.; Ferrier, A.; ...
BACKGROUND AND OBJECTIVES The subclinical pathogenesis of granulomatosis with polyangiitis (GPA) has not been completely elucidated. Proteinase 3 (PR3) antibodies are strongly associated with GPA, but have not been evaluated before disease presentation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS This was a retrospective case-control serum bank study in which PR3 antibodies and C-reactive p...
Leukocyte-derived proteases have long been considered simply degradative. However, emerging data raise possibilities of a complex and specific biologic role for these proteases in substrate processing and in signaling pathways within cells. This study reports that the release of neutrophilic and monocytic proteases, such as proteinase 3 (PR3) and human neutrophil elastase (HNE), can result in t...
Chronic obstructive pulmonary disease (COPD) is associated with tissue damage believed to result from an imbalance between serine proteinases and their inhibitors. Although the role of neutrophil elastase (NE) has been studied, it is likely that other proteinases play a role. The importance of proteinase 3 (PR3) has not been established, as specific substrates have only recently been available....
The serine proteases, neutrophil elastase (HNE) and proteinase 3 (PR3), are aberrantly expressed in human myeloid leukemias. T-cell responses to these proteins have been correlated with remission in patients with chronic myeloid leukemia (CML). Human PR3/HNE-specific CD8(+) T cells predominantly recognize a nonameric HLA-A2-restricted T-cell epitope called PR1 which is conserved in both Ags. Ho...
Thirty seven patients tested positive for antibody against proteinase 3 (anti-PR3) using either one of the two in-house ELISA methods at the Immunology Laboratory, University of Hong Kong. All except three were Chinese. Systemic vasculitis was diagnosed in 13 patients. However, the positive predictive value of anti-PR3 for Wegener's granulomatosus was low (22%). The commonest presenting feature...
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