Recent studies have shown that compounds based on a (2-nitrophenyl)methanol scaffold are promising inhibitors of PqsD, a key enzyme of signal molecule biosynthesis in the cell-to-cell communication of Pseudomonas aeruginosa. The most promising molecule displayed anti-biofilm activity and a tight-binding mode of action. Herein, we report on the convenient synthesis and biochemical evaluation of ...

Pairwise forces between particles in cosmological N-body simulations are generally softened to avoid hard collisions. Physically, this softening corresponds to treating the particles as diffuse clouds rather than point masses. For particles of unequal mass (and hence unequal softening length), computing the softened force involves a nontrivial double integral over the volumes of the two particl...

This work introduces a robust method for identifying and tracking clandestinely operating sub-nets in an active social network. The methodology is based on the Process Query System (PQS) previously applied to process mining in various physical contexts. Given a collection of process descriptions encoding personal and/or coordinated behavior of social entities, we parse a network’s transactional...

Reflective-functioning (RF) is the ability to recognize the existence and nature of mental processes taking place in the self and in others (e.g., intentions and wishes). RF was investigated here as a patient variable during the process in two studies of brief psychotherapy. The first study investigated cognitive-behavioral therapy (CBT) and interpersonal psychotherapy (IPT) in the TDCRP sample...

There has been special interest in the chemistry of quinolone and pyrimidine derivatives due to their diverse biological activities such as anticonvulsant, anti-malarial agents, antibacterial, antiviral, cytostatic, antithelemintic, antigenotoxic, anti-cancer agents. These compounds are also used as targeting delayed-type hypersensivity and anti-convulsant agents. As a part of our research work...

Multi-stage attacks can evolve dramatically causing much loss and damage to organisations. These attacks are frequently instigated by exploiting actions, which in isolation are legal and are therefore particularly challenging to detect. Much research has been conducted in the multi-stage detection area, in order to build a framework based on an events correlation approach. This paper proposes a...

Wavelet transform technique has been used for image compression targeting high visual quality reconstructed images even with high compression ratio. A visual quality measure such as Picture Quality Scale (PQS), which correlates well with the subjective Mean Opinion Score (MOS) may be employed on the compressed image for the quantizer to select the optimum dynamic threshold. The use of optimum t...

Compressing an image is significantly different than compressing raw binary data. Of course, general purpose compression programs can be used to compress images, but the result is less than optimal. The compression is achieved by many algorithms like Haar, EZW, JPEG2000 and SPIHT [4] and we can get some good results but more efficient algorithm is required which is necessary to improve the PSNR...

Bacterial cells have evolved the capacity to communicate between each other via small diffusible chemical signals termed autoinducers. Pseudomonas aeruginosa is an opportunistic pathogen involved, among others, in cystic fibrosis complications. Virulence of P. aeruginosa relies on its ability to produce a number of autoinducers, including 4-hydroxy-2-alkylquinolines (HAQ). In a cell density-dep...

Iron sequestration by host proteins contributes to the defence against bacterial pathogens, which need iron for their metabolism and virulence. A Pseudomonas aeruginosa mutant lacking all three known iron acquisition systems retains the ability to grow in media containing iron chelators, suggesting the presence of additional pathways involved in iron uptake. Here we screen P. aeruginosa mutants...