Welcome to this special issue of PPAR Research dedicated to the “Genetic Variation of PPARs.” Since PPARs are nuclear transcription factors regulating multiple genes involved in energy production, glucose and lipid metabolism, polymorphisms in these receptors may influence the pathology of numerous diseases including obesity, diabetes, atherosclerosis, inflammation and cancer. The first section...

The fibric acid derivative, fenofibrate (FF) has been used in the US since 1998 to manage patients with dyslipidemia. Typical changes in serum lipids as result a of FF treatment include clinically important mean reductions of serum triglycerides (TG) by a mean change of -93.7 mg/dL (-39.3%), increases of high density lipoprotein cholesterol (HDLC) by +5.5 mg/dL (+12.4%), and reductions in low d...

Single nucleotide polymorphisms (SNPs) play a central role in the identification of susceptibility genes for common diseases. Recent empirical studies on human genome have revealed block-like structures, and each block contains a set of haplotype tagging SNPs (htSNPs) that capture a large fraction of the haplotype diversity. Herein, we present an innovative sparse marker extension tree (SMET) a...

We observed in human and mouse skin that exposure to C. acnes resulted greatly increased epidermal lipids as indicated by bodily staining hypothesized this microbe may regulate keratinocyte lipid metabolism. To test this, keratinocytes (NHEKs) were exposed sterile supernatant showed a dose dependent increase Oil Red O (p-value <0.001), increases of ceramides, cholesterol free fatty acids detect...

Background Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and diabetes. Peroxisomes are single membrane-enclosed organelles that play a role metabolism lipid reactive oxygen species. The present study examined peroxisomes high-fat diet (HFD)-induced NAFLD using fenofibrate, peroxisome proliferator-activated receptor α (PPARα) agonist....

This study was aimed to identify miRNAs of corpus luteum (CL) in buffaloes during pregnancy. For this study, CL (n=2) were collected from gravid uteri of buffalo and RNA was isolated. Following this, the purity and integrity of RNA was checked and used for deep sequencing using Illumina Hiseq 2500 platform. The reads’ quality was checked prior to in silico analyses viz. identification of conser...