COX2 is an enzyme that belongs to the prostaglandin G/H synthase family. It consists of 604 amino acids and has a molecular weight of 68996 Da. COX2 possesses two catalytic activities and respective active sites: a cyclooxygenase (COX) that converts arachidonic acid to a prostaglandin endoperoxide, prostaglandin G2 (PGG2), and; a peroxidase (POX) that reduces PGG2 to PGH2. COX2 functions as hom...

The second observation was the error made in calculating the positive predictive value. By deÞ nition, positive predictive value is “the probability that a person actually has the disease given that he or she tests positive”.[2] In the paper under discussion, the disease was represented by VZV ELISA positives (as the gold standard) and the test was represented by “recalled history of chicken po...

M. PLUM Mathematisches Institut I, Universität Karlsruhe, Kaiserstrasse 12, D-76128 Karlsruhe, Germany [Received on 10 December 2002; revised on 12 January 2004] It is well known that routine methods of computing the spectrum of a self-adjoint operator often lead to spurious eigenvalues in a gap between two parts of the essential spectrum. We provide a geometrical explanation for a numerical me...

Diseases caused by capripox viruses affects around 650 million sheep & goats (pox diseases) and 250 million cattle (lumpy skin disease). This constitutes a massive economic burden for many resourcepoor farmers in Africa, damaging their livelihoods and ability to increase their income. The current vaccines are expensive and difficult to deliver as they need a sophisticated cold chain. The purpos...

BACKGROUND: Caprine pox virus disease play an important role in major constraints to small ruminants production in Iran. OBJECTIVES: This study was conducted in different districts of Iran to determine the prevalence of goats pox virus disease in different age groups, sex and seasons in Black goats of Iran. METHODS: In this study skin lesions of male and female goats were collected randomly ...

sure and speedy solution. For us, the interest of such investigation does not limit itself to small-pox alone, but must extend to the generality of infectious diseases. Can the infection of cholera, enteric fever, erysipelas, scarlatina, diphtheria, be conveyed by the air ? If any such facility of transportation should be established in respect of small-pox,it will become necessary to scrutinis...

this report describes the preparation of a safe and immunogenic single vaccine against capripox disease in sheep and goats using two different types of cells (primary lamb kidney and vero, a bovine turbinate cell line). this used the 0240 pox strain isolated from sheep during an outbreak. the prepared vaccine was administered subcutaneously and induced complete protection against an experimenta...