Conclusions: Six months of treatment with isoflavones had a favorable effect on serum nitrites/nitrates, homocysteine and lipid levels in Turkish women in the early postmenopausal period. Although there is not enough evidence yet from large randomized clinical trials to make a recommendation about the use of phytoestrogens for prevention of cardiovascular disease in postmenopausal years, our re...

In contrast to the relatively stable hormone profile during the middle reproductive years, the perimenopause is marked by erratic fluctuations of oestrogen and progesterone. By the late perimenopause, oestrogen levels can reach high magnitudes.1 Given the association between migraine and oestrogen ‘withdrawal’ it is not surprising that this stage of life is often accompanied by worsening migrai...

Langerhans cell histiocytosis (LCH) is a very rare disease of female genital tract, most commonly seen in vulva and unusual in postmenopausal period. Herein, we report the 8th case of pure vulvar LCH in a postmenopausal woman. We pay attention to the differential diagnosis in postmenopausal state, features of pathologic diagnosis, and treatment options.

OBJECTIVE To characterise symptoms experienced by women during the transition into natural menopause, to classify women into distinct symptom profiles or trajectories, and to relate these profiles to sociodemographic factors and health behaviours. DESIGN Nationally representative cohort study. SETTING England, Scotland, and Wales. PARTICIPANTS 695 women followed-up since birth in 1946 and...

Melatonin (MT) exerts a beneficial action in the treatment of many diseases, among them also in irritable bowel syndrome (IBS). Its secretion decreases with age, particularly, in the postmenopausal period in women. It has not been determined whether these changes can have an impact on the clinical picture of IBS. The study aimed at evaluating the urinary excretion of the main MT metabolite - 6-...

OBJECTIVES The aim of the present study is to evaluate the long term effects of estrogen-progestogen therapy (EPT) on uterine myomas volume in postmenopausal women. METHODS We performed a retrospective analysis on postmenopausal women with asymptomatic uterine myoma during the period between April, 2008 and September, 2012. Postmenopause was defined as amenorrhea for longer than a year or ser...

A research from 1983 examined the necessary dosage of oestrogen in treatment of postmenopausal bone loss and showed patients to experience bone loss in doses up to 15 micrograms and bone gain in doses above 25 micrograms of oestrogen [6]. It’s therefore plausible to assume the likely effectiveness of testosterone treatment to Osteoporotic men and of oestrogen treatment to osteoporotic women pos...

Menopause is the permanent cessation of menstruation resulting from loss of ovarian follicular activity which happens as a result of depletion of primary follicles which is basically an aging effect. Depletion of ovarian follicles is reflected as declined production of oestradiol which is currently known to be central to the morphologic and physiological changes that happen during the climacter...

Cardiovascular disease, while rare in women of reproductive age, is the main cause of mortality in menopause. The purpose of our study was to determine the association of natural menopause with cardiovascular risk factors, including their clustering into metabolic syndrome (MS). A random 5 % representative population sample of women aged 45-54 years was examined. In 575 women, we were able to d...