Lipids are essential for cellular function and tightly controlled at the transcriptional post-transcriptional levels. Dysregulation of these pathways is associated with vascular diseases, diabetes, cancer, several inherited metabolic disorders. MicroRNAs (miRNAs), in particular, a family gene repressors regulation many genes that encode proteins involved multiple lipid metabolism pathways, ther...

Methyl jasmonate (MeJA) treatment elicits induced resistance (IR) against pests and diseases in Norway spruce (Picea abies). We recently demonstrated using mRNA-seq that this MeJA-IR is associated with both a prolonged upregulation of inducible defenses defense priming. Gene expression can be regulated at transcriptional post-transcriptional level by small RNAs, including microRNAs (miRNAs). He...

Long regulatory elements (LREs), such as CpG islands, polydA:dT tracts or AU-rich elements, are thought to play key roles in gene regulation but, opposed conventional binding sites of transcription factors, few methods have been proposed formally and automatically characterize them. We present here a computational approach named DExTER (Domain Exploration To Explain Regulation) dedicated the id...

this study was done to gain insights into transcriptional regulation of negative energy balance (neb) assoctiated genes. overexpressed genes in neb were identified using microarray and rna-seq data and promoter analysis of these overexpressed genes was applied to identify novel transcription factors. moreever, string database was used to construct a regulatory network of identified transcriptio...

κ-casein is a glycosilated protein in mammalian milk that plays an essential role in the milk micelles. control of κ-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other milk protein genes. transcriptional regulation, a first mechanism for controlling the development of organisms, is carried out by transcription facto...

The goal of our workshop is to introduce some recent work in the area of post-transcriptional regulation to a wider computational community, discuss some of the unique computational problems faced in this area, and to present some preliminary solutions to these problems. In particular, we will focus on emerging computational and large-scale experimental strategies (e.g. microarray and deep sequ...