نتایج جستجو برای: pore system

تعداد نتایج: 2266274  

Journal: :Biomaterials 2006
Bungo Otsuki Mitsuru Takemoto Shunsuke Fujibayashi Masashi Neo Tadashi Kokubo Takashi Nakamura

A porous structure comprises pores and pore throats with a complex three-dimensional (3D) network structure, and many investigators have described the relationship between average pore size and the amount of bone ingrowth. However, the influence of network structure or pore throats for tissue ingrowth has rarely been discussed. Four types of bioactive porous titanium implants with different por...

Journal: :Science 2004
Martin Beck Friedrich Förster Mary Ecke Jürgen M Plitzko Frauke Melchior Günther Gerisch Wolfgang Baumeister Ohad Medalia

Nuclear pore complexes (NPCs) are gateways for nucleocytoplasmic exchange. To analyze their structure in a close-to-life state, we studied transport-active, intact nuclei from Dictyostelium discoideum by means of cryoelectron tomography. Subvolumes of the tomograms containing individual NPCs were extracted in silico and subjected to three-dimensional classification and averaging, whereby distin...

Journal: :Methods in molecular biology 2016
Samson O Obado Mark C Field Brian T Chait Michael P Rout

Functional understanding of the nuclear envelope requires the identification of its component proteins and their interactions. Trypanosomes cause human and livestock diseases worldwide but are so divergent from animals and fungi that in silico searches for homologs of proteins are frequently of low value. Here we describe a strategy for the straightforward identification of nuclear envelope pro...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1975
R P Aaronson G Blobel

Nuclear pore complexes have been isolated in association with a 150 A thick lamina by detergent and salt fractionation of nuclear envelopes from rat liver. The pore complexes exhibit characteristic morphology and appear to be attached in a highly specific orientation to the lamina, which extends over relatively large areas. The pore complex-lamina fraction is composed of three major and several...

2017
Fei Song Peng Wang Shangxing Chen Zongde Wang Guorong Fan

By using dehydroabietyltrimethyl ammonium bromine (DTAB), a novel rosin-derived quaternary ammonium salt, as template and peroxotitanium acid as precursor, ordered lamellar supermicroporous titania has been synthesized via a hydrothermal process. The template agent:titanium source molar ratio in the synthesis system and the hydrothermal temperature have great impact on the microstructure charac...

Journal: :Journal of biotechnology 2013
Andreas Bertz Stefanie Wöhl-Bruhn Sebastian Miethe Brigitte Tiersch Joachim Koetz Michael Hust Heike Bunjes Henning Menzel

Novel hydrogels based on hydroxyethyl starch modified with polyethylene glycol methacrylate (HES-P(EG)₆MA) were developed as delivery system for the controlled release of proteins. Since the drug release behavior is supposed to be related to the pore structure of the hydrogel network the pore sizes were determined by cryo-SEM, which is a mild technique for imaging on a nanometer scale. The resu...

Journal: :ACS nano 2011
Yu Gao Yu Chen Xiufeng Ji Xinyu He Qi Yin Zhiwen Zhang Jianlin Shi Yaping Li

In this work, hollow mesoporous silica nanoparticles (HMSNs) with three pore sizes were manufactured to control the drug release rate, and the biological roles of these HMSNs were evaluated in multidrug-resistant (MDR) cancer cells. As novel pore-size-controllable inorganic materials, HMSNs showed negligible cytotoxicity and efficient cellular uptake toward drug-sensitive MCF-7 and drug-resista...

Journal: :The Journal of biological chemistry 2012
Élise Faure Greg Starek Hugo McGuire Simon Bernèche Rikard Blunck

Voltage-gated ion channels are responsible for the generation of action potentials in our nervous system. Conformational rearrangements in their voltage sensor domains in response to changes of the membrane potential control pore opening and thus ion conduction. Crystal structures of the open channel in combination with a wealth of biophysical data and molecular dynamics simulations led to a co...

2014
Jaeyun Kim Weiwei Aileen Li Warren Sands David J. Mooney

The in vivo enrichment of dendritic cells (DCs) in implanted macroporous scaffolds is an emerging strategy to modulate the adaptive immune system. The pore architecture is potentially one of the key factors in controlling enrichment of DCs. However, there have been few studies examining the effects of scaffold pore structure on in vivo DC enrichment. Here we present the effects of surface poros...

Journal: :American journal of physiology. Cell physiology 2014
Prattana Samasilp Kyle Lopin Shyue-An Chan Rajesh Ramachandran Corey Smith

Adrenal neuroendocrine chromaffin cells receive excitatory synaptic input from the sympathetic nervous system and secrete hormones into the peripheral circulation. Under basal sympathetic tone, modest amounts of freely soluble catecholamine are selectively released through a restricted fusion pore formed between the secretory granule and the plasma membrane. Upon activation of the sympathoadren...

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