As one of the major glutathione conjugation enzymes, GSTM1 detoxifies a number of drugs and xenobiotics. Its expression and activity have been shown to correlate both with cancer risks and drug resistance. Through a genome-wide association study, we identified a significant association between HapMap SNP rs366631 and GSTM1 expression. In this study, utilizing lymphoblastoid cell lines derived f...

-The understanding of the speciation process can best be achieved by a knowledge of the genic differences between two closely related species and the correlation of such differences with the characteristics which demarcate the two species. D. persimilis and D. pseudoobscura are two sibling species differing from each other in morphology, ecological preferences, and behavior, and no hybrids exis...

Whole-genome sequence data from samples of natural populations provide fertile grounds for analyses of intraspecific variation and tests of population genetic theory. We show that the urochordate Ciona savignyi, one of the species of ocean-dwelling broadcast spawners commonly known as sea squirts, exhibits the highest rates of single-nucleotide and structural polymorphism ever comprehensively q...