Enhancement of solubility is one of the difficult tasks which become challenges in formulation development of orally administered drug with poor aqueous solubility. Poor water solubility of drugs often causes significant problems in producing formulations of sufficiently high bioavailability, preventing effective use of the drugs. 'Mixed-solvency ' concept is the phenomenon to increase the solu...

Self nano emulsifying drug delivery systems (SNEDDs) gained much attention in the last decades since, such considered one of most favorable and efficient approaches to enhance solubility, increase absorption hence, its oral bioavailability poorly water soluble (lipophilic) moieties. Owing their unique properties advantages over other conventional dosage forms, many literatures investigate chang...

Low oral bioavailability as a consequence of low water solubility of drugs is a growing challenge to the development of new pharmaceutical products. One of the most popular approaches of oral bioavailability and solubility enhancement is the utilization of lipid-based drug delivery systems. Their use in product development is growing due to the versatility of pharmaceutical lipid excipients and...

Adequate aqueous solubility has been one of the desired properties while selecting drug molecules and other bio-actives for product development. Often solubility of a drug determines its pharmaceutical and therapeutic performance. Majority of newly synthesized drug molecules fail or are rejected during the early phases of drug discovery and development due to their limited solubility. Sufficien...

Nanosuspension is a novel drug formulation for the delivery of hydrophobic drugs. The problem medications that are poorly water-soluble and have low bioavailability countered by nanosuspension technology. Solubility significant physiochemical element influences absorption therapeutic effectiveness. Poor aqueous solubility has potential to impair development. technology can improve drug's stabil...

Drug combinations have been the hotspot of pharmaceutical industry, but promising applications are limited by unmet solubility and low bioavailability. In this work, novel cocrystals, consisting two antithrombotic drugs with poor bioavailability in vivo, namely, apixaban (Apx) quercetin (Que), were developed to discover a potential method improve internal absorption drug combination. Compared A...