نتایج جستجو برای: poor asthma treatment
تعداد نتایج: 1632622 فیلتر نتایج به سال:
Asthma is the most common chronic illness of childhood, affecting up to 14% of children. Poor asthma management and non-adherence to treatment regimens are a pervasive problem in this population and are related to exacerbation of symptoms. Effective management of pediatric asthma involves a complex set of interactions between the parent and child, yet there is a paucity of literature examining ...
PURPOSE OF REVIEW This review summarizes the importance of macrolide therapy in the treatment of asthma, discusses macrolide mechanisms of action, and outlines new clinical data supporting their use. The effects of macrolides on both the innate and adaptive immune responses are discussed. RECENT FINDINGS Subacute bacterial infection with both typical and atypical organisms contributes to poor...
Information was obtained from 336 21-year-olds who had begun wheezing before the age of 7 about their knowledge of asthma and its effect on their current life style. Twothirds of the subjects were still symptomatic. A control group of 62 subjects was available for comparison. Knowledge about asthma was poor, particularly among those with less troublesome symptoms. Half of those with frequent ep...
Poor asthma control is associated with increased airway neutrophils. Leukotriene B4 (LTB4) is a potent neutrophil chemoattractant. We examined the levels of LTB4 levels in the sputum of asthma patients and the relationship with disease severity. 47 asthma patients (categorised according to Global Initiative for Asthma treatment stage) and 12 healthy controls provided sputum samples that were pr...
❚ Received: May 5, 2016 – Accepted June 17, 2016 ❚ Correspondence: Fabio Perrotta, Department of Cardio-Thoracic and Respiratory Sciences Second University of Naples, Monaldi Hospital, via L. Bianchi, 80131 Naples, Italy Tel. +39 081 5453017 E-mail: [email protected] Asthma is a heterogeneous chronic inflammatory lung disease originating from a complex interaction between individual and envir...
asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active drugs. to solve this paradox, we need objective airway biomarkers to tailor the proper medica...
Background The asthma epidemic in industrialised countries has been explained by the ‘hygiene hypothesis’, according to which early life infections protect against allergic diseases. However, current high asthma rates in Latin American cities seem to be associated with poor hygienic conditions, overcrowding and infections. The aim of the review was to summarise the role of poor hygiene exposure...
There has been a sharp increase in the global prevalence, morbidity, mortality, and economic burden associated with asthma over the last 40 years, particularly in children. Approximately 300 million people worldwide currently have asthma, and its prevalence increases by 50% every decade. In North America, 10% of the population have asthma. Asthma is underdiagnosed and undertreated, although the...
Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and annually updated a global strategy for asthma management and prevention that has formed the basis for many national guidelines. However, uptake of existing guidelines is poor. A major revision of the GINA report was published in 2014, and updated in 2015, reflecting an evolving understanding of heterogen...
Background and purpose: Asthma is a chronic inflammatory disorder of the airways caused by a combination of complex environmental and genetic interactions. There is an incomplete understanding of this mechanism which affect both severity of the disease and how it responds to treatment. Different gene expressions are reported in patients with asthma and healthy controls. Materials and methods:...
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