The article is devoted to the study of process obtaining a new water-soluble complex imino derivative gossypol, its physicochemical and structural parameters. N-polyvinylpyrrolidone (N-PVP, M.m. 8000) for medical use was chosen obtain gossypol. During study, we tested methods several complexes, which are proposed in classical literature information resources. following method used complex: goss...

Objectives. The study aimed to investigate the biological activity of C 60 /poly-N-vinylpyrrolidone (C /PVP) complex representing a water-soluble fullerene derivative. In vitro and in vivo techniques were used analyze effect /PVP on lactate dehydrogenase (LDH) evaluate changes biochemical parameters blood serum when per os administered mice. Methods . order determine commercial LDH preparation ...

Here we report on the organometallic synthesis of polyvinylpyrrolidone (PVP)-stabilized palladium-rhodium nanostructures that display high electrochemical properties when used as carbon-supported electrodes (PdxRh1-x-PVP/C) for methanol oxidation reaction (MOR). These were synthesized by hydrogenation tris(dibenzylideneacetone)dipalladium(0) (Pd2(dba)3) and tris(allyl) rhodium (Rh(?3-C3H5)3) co...

OBJECTIVES Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND METHODS Solid dispersions of CLX:PVP or CLX:PLX were prepared at different ra...

The aim of this study was to develop celecoxib (CLX) -polyvinylpyrrolidone (PVP) solid dispersion nanoparticles with and without surfactant using the supercritical antisolvent (SAS) process. effect different surfactants such as gelucire 44/14, poloxamer 188, 407, Ryoto sugar ester L1695, D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) on nanoparticle formation dissolution well oral abs...

A study of the H-bonding between poly(ethylene glycol) (PEG) and polyvinylpyrrolidone (PVP) in the presence of supercritical carbon dioxide at various temperatures, pressures, different M(w) of PEG and PVP and different PEG/PVP ratios is presented. In situ attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy was used to investigate H-bonding by examining changes in the...

Copper nanoparticles (CuNPs) embedded in polyvinylpyrrolidone (PVP) and polyethylene oxide (PEO) fiber-matrices were prepared through centrifugal spinning of PVP/ethanol PEO/aqueous solutions, respectively. The prime focus the current study is to investigate antibacterial activity composite fibers against Escherichia coli (E. coli) Bacillus cereus (B. cereus) bacteria. During fiber formation, p...

Polymer blend electrolytes have been prepared using the casting technique. The electrolyte is composed of two polymers polyvinyl alcohol (PVA)/polyvinylpyrrolidone (PVP)) with a fixed ratio (50 : 50) loaded varied ratios FeCl2 (0.5, 1, and 2 wt.%). impedance analysis indicates that AC conductivity increased as temperature was following power law. Nyquist plots for pure composite samples present...

The objective of the present investigation was to study the influence of polyethylene glycol 4000 (PEG) and polyvinylpyrrolidone K30 (PVP) on in vitro dissolution of etoricoxib from solid dispersions. Preliminary studies were carried out using a physical mixture of the drug and carriers. Solid dispersions were prepared using the solvent evaporation method. A 32 factorial design was adopted in t...

This work aims at evaluating advancement in water shut-off performance using nanocomposite hydrogel (PVP-ZnO:RF) prepared from PolyVinylPyrrolidone (PVP); used as polymer, Resorcinol-Formaldehyde (RF); a crosslinker and nano Zinc Oxide (ZnO); strength modifier it was compared with conventional (PVP:RF) i.e. , without ZnO nanofiller. The ZnO, nanofiller this work, successfully bio-synthesized ( ...