Background: Telmisartan (TEL) is an orally active nonpeptide angiotensin II antagonist drug. The drug acts on a subtype of AT1 receptors, which serves to cope with high blood pressure (hypertension). TEL class Biopharmaceutical Classification System (BCS), that has low solubility in water and permeability. Objectives: This study aims determine the effect formation TEL-PVP K-30 nanoparticles thr...