The specific aim of our investigation is to study the potential use of a collagen/heparin-carrying polystyrene (HCPS) composite extracellular matrix for articular cartilage tissue engineering. Here, we created a high-performance extracellular matrix (HpECM) scaffold to build an optimal extracellular environment using an HCPS we originally developed, and an atelocollagen honeycomb-shaped-scaffol...

Currently, the most commonly used bioresorbable scaffold is made of beta-tricalcium phosphate (β-TCP); it is hoped that scaffolds made of a mixture of hydroxyapatite (HA) and poly-D/L-lactide (PDLLA) will be able to act as novel bioresorbable scaffolds. The aim of this study was to evaluate the utility of a HA/PDLLA scaffold compared to β-TCP, at a loading site. Dogs underwent surgery to replac...

Bioactive composite macroporous scaffold containing nanoporosity was prepared by incorporation of nanoporous magnesium silicate (NMS) into poly(butylene succinate) (PBSu) using solvent casting-particulate leaching method. The results showed that the water absorption and in vitro degradability of NMS/PBSu composite (NMPC) scaffold significantly improved compared with magnesium silicate (MS)/PBSu...

We describe and apply a scaffold-focused virtual screen based upon scaffold trees to the mitotic kinase TTK (MPS1). Using level 1 of the scaffold tree, we perform both 2D and 3D similarity searches between a query scaffold and a level 1 scaffold library derived from a 2 million compound library; 98 compounds from 27 unique top-ranked level 1 scaffolds are selected for biochemical screening. We ...

In this study, a three-dimensional chitosan-gelatin/nanohydroxyapatite (ChG/nHaP) scaffold was successfully fabricated and characterized in terms of swelling, degradation, cell proliferation, cell attachment, and mineralization characterizations. The ChG/nHaP scaffold was fabricated with a mean pore size of 100-180 μm. Our results showed that the physicochemical and biological properties of the...

introduction: the native inability of nervous system to regenerate, encourage researchers to consider neural tissue engineering as a potential treatment for spinal cord injuries. considering the suitable characteristics of induced pluripotent stem cells (ipscs) for tissue regeneration applications, in this study we investigated the adhesion, viability and proliferation of neural progenitors (de...

collagen is the major protein component of cartilage, bone, skin and connective tissue and constitutes the major part of the extracellular matrix. collagen type i has complex structural hierarchy, which consists of treepolypeptide α-chains wound together in a rod-like helical structure. collagen is an important biomaterial, finding many applications in the field of tissue engineering. it has be...

objective: this study examined the in vivo differentiation of mesenchymal stem cells (mscs) into insulin producing cells (ipcs) on electrospun poly-l-lactide acid (plla) scaffolds coated with matricaria chammomila l. (chamomile) oil. materials and methods: in this interventional, experimental study adipose mscs (amscs) were isolated from 12 adult male new zealand white rabbits and characterized...