Fibrous dysplasia (FD) is a monostotic or polyostotic benign bone lesion with spindle-cell proliferation in woven bone and stroma. Rarely, cartilaginous differentiation can be seen in the lesions of FD. FD with massive cartilaginous differentiation is called fibrocartilaginous dysplasia (FCD) and is considered a rare variant of FD. Although pathological findings of FD show irregular immature bo...

A coalition is a congenital bony, cartilaginous, or fibrous connection (called a bar) between two or more bones. Coalitions are clinically significant because they prevent normal joint motion. Tarsal coalition may be difficult to identify on clinical and imaging evaluation. Given the high prevalence of coalition, radiologists must be alert to the often subtle imaging findings.

Figure Legend: Figure 1 Bone Fibrous osteodystrophy in a male F344/N rat from a chronic study. There is replacement of bone by fibrous connective tissue. Figure 2 Bone Fibrous osteodystrophy in a male F344/N rat from a chronic study (same animal as in Figure 1). There is replacement of cortical bone by fibrous connective tissue. Figure 3 Bone Fibrous osteodystrophy in a male F344/N rat from a c...

BACKGROUND & OBJECTIVES Fibrous dysplasia (FD) is a rare metabolic bone disease and information available from India is limited to only anecdotal case reports. We describe the clinical profile and therapeutic outcome of 25 patients with FD observed over a period of 14 yr in a tertiary care centre from north India. METHODS In this retrospective study patients (n = 25) with diagnosis of fibrous...

The authors report the results of the management of five consecutive children with McCune-Albright syndrome. These children were treated with a combination of drug treatment (bisphosphonates) and surgical treatment with elongating intramedullary rods (Sheffield) for management of femoral and tibial lesions. This treatment was successful in all patients, as judged by improvement in their quality...

Fibrous dysplasia is a kind of benign bone lesion characterized by the manifestation of the replacement of the normal substance of bone by fibro-osseous connective tissue. A patient diagnosed fibrous dysplasia had unbearable pain in the left mandibular region only. To treat the patient, an navigation template was designed to guide the decompression of inferior alveolar nerve, and piezosurgery w...

The mainstay of treatment of craniofacial dysplasia (CFD) remains surgery once clinical observation has been excluded. Nevertheless, disagreement remains about the type of surgical intervention (remodelling versus radical resection). The aim of this paper is to present our experience until 2013 comparing CFD management between 1980 and 2002 and between 2003 and 2013 and to propose our surgical ...

Secondary osteosarcoma from fibrous dysplasia (FD) is very rare. The etiology of FD is linked to activating missense mutations of the guanine nucleotide-binding protein α-subunit (GNAS) gene, which encodes the stimulatory α subunit of the G protein (Gsα) and is located at chromosome 20q13. These mutations are central to the pathogenesis of FD; however, it is not known whether Gsα mutations are ...