The discovery and development of antimicrobial agents that do not give rise to resistance remains an ongoing challenge. Our efforts in this regard continue to reveal new potential therapeutic agents with differing physicochemical properties while retaining the effective N,N-dichloroamine pharmacophore as the key antimicrobial warhead. In this Letter, we disclose agents containing polyol units a...

There is relatively little published information regarding consumer perceptions of the possible health benefits or occurrence of gastrointestinal symptoms following consumption of low-digestible carbohydrates (LDCs), in particular polyol sugars. This workshop focused on how consumers perceive the possible health benefits of LDCs, their reactions to any `adverse' symptoms following LDC consumpti...

In this research we evaluated the calcium channel antagonist activity of various diester analohues of nifedipine on rat ileal smooth muscle.in these analogues,the orthophenyl group at position 4 was replaced by 1 methyl 2-meythylsulfonyl or methylthio 5-imidazolyl.wistar rats(180-250g) were killed by a blow to the head.the intestine was removed above the ileucecal junction and longitudinal smoo...

Monodispersed FePt nanoparticles are synthesized by reduction of iron(II) acetylacetonate and platinum(II) acetylacetonate with 1,2-hexadecanediol as the reducing reagent in the polyol process. As-prepared FePt nanoparticles are chemically disordered with fcc phase. Transmission electron microscopy (TEM) images show a self-assembled particle array with an average particle size of 3 nm and a sta...

Abstract Palm oil polyol-based foams have inflexible and brittle properties. polyols a lower molecular weight. Polyols with high weight primary OH group, such as polyethylene glycol (PEG)-400, can provide the flexible properties of polyurethane foam. This study aimed to examine optimum concentration PEG-400, which produce foam made from palm best characteristics based on mechanical compared pol...

Conjugation of methotrexate (MTX) (MW 454) with different molecular weights of polyethylene glycol (PEG) including methoxy-peg (mpeg) 750 D and 5000 D and diol-peg 35000 D led to compounds that are physicochemically highly different from the parent compound, MTX. In this study, an HPLC system consisting of C8 column and UV detector (?=342 nm), using a mixture of 30:70 v/v phosphate-citrate buff...

Sorbitol dehydrogenase was isolated from human brain and purified 690-fold, giving a final specific activity of 11.1 units/mg of protein. The enzyme preparation was nearly homogeneous, but was unstable at most temperatures. It exhibited a broad pH optimum of 7.5-9.0 in the forward reaction (i.e. sorbitol -+fructose), and of 7.0 in the reverse reaction (i.e. fructosesorbitol). Substrate-specific...

A most effective and less energy demanding method of producing fatty esters, diol esters, by esterifying fatty acids, with neopentyl and ethylenglycol alcohols in the presence of an acidic ion exchange resin catalyst(polyestyrendivinylbenzensulfated) was investigated at elevated temperature. In this process an azeotroping agent, toluene, was used to facilitate continuous removal of water by dis...

The aim of the present work was to study physicochemical, textural and sensory properties biscuits prepared by replacing sucrose with rare sugar (D-psicose) and/or polyols (sorbitol, xylitol) at 25% or 50%. results showed that increasing D-psicose replacement resulted in lower moisture content, darker less yellow, thicker biscuits. However, opposite effects were observed polyol substitute textu...

The geometry of metal nanoparticles greatly affects the properties of the localized surface plasmon resonance and surface-enhanced Raman scattering. The synthesis of metal nanoparticles with controllable geometry has thus attracted extensive attentions. In this work, we report a modified polyol synthesis approach of silver (Ag) nanocubes through tuning the concentration of bromide ions (Br(-) i...