نتایج جستجو برای: polymorphism il6

تعداد نتایج: 109750  

2015
Gabriele Di Sante Shaohua Xu Qiong Wang Kevin Li Xin Sun Congwen Xu Zhiping Li Mathew C. Casimiro Adam Ertel Sankar Addya Peter A. McCue Michael P. Lisanti Chenguang Wang Richard J. Davis Graeme Mardon Richard G. Pestell

Prostate cancer is the second leading form of cancer-related death in men. In a subset of prostate cancer patients, increased chemokine signaling IL8 and IL6 correlates with castrate-resistant prostate cancer (CRPC). IL8 and IL6 are produced by prostate epithelial cells and promote prostate cancer cell invasion; however, the mechanisms restraining prostate epithelial cell cytokine secretion are...

2015
Nick Powell Jonathan W. Lo Paolo Biancheri Anna Vossenkämper Eirini Pantazi Alan W. Walker Emilie Stolarczyk Francesca Ammoscato Rimma Goldberg Paul Scott James B. Canavan Esperanza Perucha Natividad Garrido-Mesa Peter M. Irving Jeremy D. Sanderson Bu Hayee Jane K. Howard Julian Parkhill Thomas T. MacDonald Graham M. Lord

BACKGROUND & AIMS Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal inflammatory cells that participate in chronic intestinal inflammation. We investigated the role of interleukin 6 (IL6) in inducing activation of ILCs in mice and in human beings with chronic intestinal inflammation. METHODS ILCs were isolated from colons of Tbx21(-/-) × Rag2(-/-) mice (TRUC), which develop co...

2018
Lluc Mosteiro Cristina Pantoja Alba de Martino Manuel Serrano

Cellular senescence is a damage response aimed to orchestrate tissue repair. We have recently reported that cellular senescence, through the paracrine release of interleukin-6 (IL6) and other soluble factors, strongly favors cellular reprogramming by Oct4, Sox2, Klf4, and c-Myc (OSKM) in nonsenescent cells. Indeed, activation of OSKM in mouse tissues triggers senescence in some cells and reprog...

Journal: :Cardiovascular research 1999
H Matsui Y Ihara Y Fujio K Kunisada S Akira T Kishimoto K Yamauchi-Takihara

OBJECTIVES We have previously reported that interleukin (IL)-6 is induced by hypoxic stimulation in cardiac myocytes. In the present study, we examined the induction of potent transcription factors of IL-6, nuclear factor (NF)-kappa B and NF-IL6, in cardiac myocytes subjected to hypoxia. METHODS Five different lengths of IL-6 promoter-luciferase reporter plasmids and three mutant plasmids, in...

Journal: :Annals of the rheumatic diseases 2004
M C Kraan T J M Smeets M J van Loon F C Breedveld B A C Dijkmans P P Tak

BACKGROUND T cells have a pivotal role in RA. Leflunomide inhibits pyrimidine biosynthesis, to which T cells are especially susceptible, and therefore may have a different cytokine profile than methotrexate. MATERIALS AND METHODS Serum samples of 100 patients with RA, treated with leflunomide (n = 50) or methotrexate (n = 50), were collected at baseline, after 16 weeks and after 1 year's trea...

Journal: :Clinical immunology 2010
Risa K Benwell David R Lee

Requirements for human Th17 differentiation in the context of activated dendritic cells (DCs) are still emerging. Here, we demonstrate that several Toll-like receptor (TLR) ligands, particularly LPS and a synthetic lipoprotein, activate human DCs to direct increased human Th17 differentiation. Based on neutralization studies, IL1, IL6, and TGFbeta contributed to human Th17 differentiation induc...

Journal: :Cell 2009
Dimitrios Iliopoulos Heather A. Hirsch Kevin Struhl

Inflammation is linked clinically and epidemiologically to cancer, and NF-kappaB appears to play a causative role, but the mechanisms are poorly understood. We show that transient activation of Src oncoprotein can mediate an epigenetic switch from immortalized breast cells to a stably transformed line that forms self-renewing mammospheres that contain cancer stem cells. Src activation triggers ...

Journal: :Cancer research 2015
Ke Chen Kongming Wu Xuanmao Jiao Liping Wang Xiaoming Ju Min Wang Gabriele Di Sante Shaohua Xu Qiong Wang Kevin Li Xin Sun Congwen Xu Zhiping Li Mathew C Casimiro Adam Ertel Sankar Addya Peter A McCue Michael P Lisanti Chenguang Wang Richard J Davis Graeme Mardon Richard G Pestell

Prostate cancer is the second leading form of cancer-related death in men. In a subset of prostate cancer patients, increased chemokine signaling IL8 and IL6 correlates with castrate-resistant prostate cancer (CRPC). IL8 and IL6 are produced by prostate epithelial cells and promote prostate cancer cell invasion; however, the mechanisms restraining prostate epithelial cell cytokine secretion are...

2009
Dimitrios Iliopoulos Heather A. Hirsch Kevin Struhl

Inflammation is linked clinically and epidemiologically to cancer, and NF-kB appears to play a causative role, but the mechanisms are poorly understood. We show that transient activation of Src oncoprotein can mediate an epigenetic switch from immortalized breast cells to a stably transformed line that forms self-renewing mammospheres that contain cancer stem cells. Src activation triggers an i...

2003
Anne Vink Pierre Coulie Guy Warnier Jean-Christophe Renauld Monique Stevens Dominique Donckers Jacques Van Snick

Murine plasmacytomas show a striking dependence on interleukin 6 (IL6) for their growth in vitro . Here, we present evidence suggesting that IL6 also plays an essential role in the in vivo development of these tumors . This conclusion is based on the finding that the tumorigenicity of an IL-6-dependent plasmacytoma cell line was increased -100-fold on transfection with an IL-6 expression vector...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید