The structure solution of the δ-polymorph indomethacin was obtained using three-dimensional electron diffraction. This form shows a significantly enhanced dissolution rate compared with more common and better studied α- γ-polymorphs, indicating biopharmaceutical properties for medicinal applications. solved in non-centrosymmetric space group P21 comprises two molecules asymmetric unit. Packing ...

Two polymorphs of a substituted dihydroanthracene derivative were prepared by crystallization from different solvents. Each polymorph is reversibly interconvertible to the other by means of a single-crystal to single-crystal phase transformation.

Calcium carbonate aragonite polymorph nanoparticles derived from cockle shells were prepared using surface functionalization method followed by purification steps. Size, morphology, and surface properties of the nanoparticles were characterized using transmission electron microscopy, field emission scanning electron microscopy, dynamic light scattering, zetasizer, X-ray powder diffraction, and ...

In this paper, we report the results of quality control based in physicochemical characterization and impurities determination of three samples of fluconazole drug substances marketed in Morocco. These samples were supplied by different pharmaceuticals companies. The sample A, as the discovered product, was supplied by Pfizer, while samples B and C (generics), were manufactured by two different...

Barbital is a hypnotic agent that has been intensely studied for many decades. The aim of this work was to establish a clear and comprehensible picture of its polymorphic system. Four of the six known solid forms of barbital (denoted I(0), III, IV, and V) were characterized by various analytical techniques, and the thermodynamic relationships between the polymorph phases were established. The o...

The title complex, [AuCl{(C(6)H(5))(2)P(OH)-κP}] or [AuCl(C(12)H(11)OP)], contains two independent mol-ecules in the asymmetric unit and is a polymorph of a previously reported structure [Hollatz et al. (1999 ▶) J. Chem. Soc. Dalton Trans. pp. 111-114]. The crystal structure exhibits inter-molecular Au⋯Au inter-actions with alternate distances of 3.0112 (3) Å and 3.0375 (2) Å. The Cl-Au-P bond ...