Chromatin insulators, or boundary elements, affect promoter-enhancer interactions and buffer transgenes from position effects. The gypsy insulator of Drosophila is bound by a protein complex with two characterized components, the zinc finger protein Suppressor of Hairy-wing [Su(Hw)] and Mod(mdg4)2.2, which is one of the multiple spliced variants encoded by the modifier of mdg4 [mod(mdg4)] gene....

Transcriptional insulators are specialized cis-acting elements that protect promoters from inappropriate activation by distal enhancers. The H19 imprinting control region (ICR) functions as a CTCF-dependent, methylation-sensitive transcriptional insulator. We analyzed several insertional mutations and demonstrate that the ICR can function as a methylation-regulated maternal chromosome-specific ...

Chromatin boundaries or insulator elements affect the interaction between enhancers and promoters. The gypsy insulator contains two proteins, Su(Hw) and Mod(mdg4). Both proteins colocalize on several hundred sites on polytene chromosomes and are distributed in a punctated pattern in the nuclear matrix. Mutations in mod(mdg4) have properties characteristic of a trxG gene. In addition, mutations ...

CTCF plays a central role in vertebrate insulators and forms part of the Fab-8 insulator in Drosophila. dCTCF is present at hundreds of sites in the Drosophila genome, where it is located at the boundaries between bands and interbands in polytene chromosomes. dCTCF colocalizes with CP190, which is required for proper binding of dCTCF to chromatin, but not with the other gypsy insulator proteins...

bituminous emulsion insulators are types of bituminous emulsions groups composed of different grades of bitumen emulsified in water by bentonite and emulsifiers at 80-90oc. these emulsions are water resistant after drying andtheir physical and mechanical properties are superior in comparison to bitumen properties. iranian climate, because of variety and extreme variations in temperature imposes...

Background Carbon Nanotube Field Effect Transistors (CNTFETs) have high charge sensitivity at room temperature [1]. By using this sensitivity, some nonvolatile memory devices have been demonstrated with charge trapping in SiO 2 gate insulator [2, 3]. Besides, a new design of synapse-like circuit requires a multi-level nonvolatile memory [4]. For this application, and according to its high charg...

The effect of pressure on the metal–insulator transition in manganites with a broad range of bandwidths is investigated. A critical pressure is found at which the metal–insulator transition temperature, TMI , reaches a maximum value in every sample studied. The origin of this universal pressure and the relation between the pressure effect and the bandwidth on the metal–insulator transition are ...

The ground-state phase diagrams of the Falicov-Kimball model with local disorder are derived within the dynamical mean-field theory and using the geometrically averaged s“typical”d local density of states. Correlated metal, Mott insulator, and Anderson insulator phases are identified. The metal-insulator transitions are found to be continuous. The interaction and disorder compete with each othe...

In this Letter we construct a simple, controllable, two-dimensional model based on a topological band insulator. It has many attractive properties. (1) We obtain spin-charge separated solitons that are associated with dynamic pi fluxes. (2) These solitons obey Bose statistics and their condensation triggers a phase transition from a spin Hall insulator to an easy-plane ferromagnet. (3) It sugge...