objective: pmbn, poly [2-methacryloyloxyethyl phosphoryl choline (mpc)-co-n- buthyl methacrylate (bma)-co-p-nitrophenyl- oxycrabonyl poly (ethylene glycol-methacrylate (meonp)], as a biocompatible ter-polymer is a unique polymer with wide range of application from drug delivery systems to scaffolds and biomedical devices. in this research, monomer of p- nitrophenyl- oxycarbonyl poly (ethylene g...

Despite the advantages of transdermal drug delivery (TDD), which makes it a fast-growing area research in pharmaceutics, numerous challenges affect their development, limits exploring full potential this alternate route. In trying to address one these problems, is strongly believed that need for sustainable skin alternative paramount. Efforts made an attempt provide employing pharmaceutical ana...

Cellulose based polymers have shown tremendous potential as drug delivery carrier for oral drug delivery system (DDS). Hydroxyethyl cellulose (HEC) and hydroxypropyl cellulose (HPC) are widely explored as excipients to improve the solubility of poorly water soluble drugs and to improve self-life of dosage form. This work is an attempt to modulate the physicochemical properties of these cellulos...

Fully atomistic molecular dynamics simulations were employed in order to examine in detail the self-assembly characteristics and the complexation behavior of the anticancer drug doxorubicin with PEGylated hyperbranched polyesters in an aqueous environment. We have examined two variants of the polymeric compound by altering the length of the hydrophilic poly(ethylene glycol) arms attached to the...

Background & rationale Over time, it has become clear that despite their dramatic success in tackling coronary restenosis, first generation drug-eluting stents (DES) are associated with a small but significant excess of adverse events late after stent implantation (>12 months), in particular, late stent thrombosis and delayed loss of antirestenotic eff icacy [1–4]. The central process underlyin...

the conducting polymer films have been widely applied in the field of electrochemistry owing to their goodstability, permselectivity, unique physical and chemical properties. a novel nano-au/poly (4-aminobenzoicacid) (paba) film modified carbon paste electrode was fabricated for sensitive detection of acetaminophenin this paper. the paba film and nano-au/paba film were characterized by scanning...

Background: In recent years, nanotechnology with modern advances in the macromolecular design of nano-carriers has proved to be helpful in the development of drugs delivery systems. This research represents a novel co-administration of nano-vehicles, known as liposomes. Liposomes efficiently encapsulate curcumin and bromocriptine (BR) in a polymer structure, which results in enhanced aqueous so...

In this study, we fabricated PCL-nanoparticles by encapsulating dual drugs as amphotericin B and doxorubicin via double-emulsion solvent evaporation method also incorporated with ligand-lectin for targeting the infested macrophage cells and prove importance against VL. Different independent processing parameters were assessed systematically to enhance the incorporation of the dual agents with d...

The use of supercritical fluids in the area of material processing and for particle formation has been known for several years now. The advantages of supercritical fluid processing include mild operating temperatures, production of solvent free particles and easy micro encapsulation of particles. One of the attractive methods of particle processing using supercritical fluid is the Supercritical...

Age and diabetes related slow-healing or chronic wounds may result in morbidity mortality through persistent biofilms infections prolonged inflammatory phase. Nano-materials [metal/metal oxide NPs (39%), lipid vehicles (21%), polymer (19%), ceramic nanoparticles (NPs) (14%), carbon nanomaterials (NMs) (7%)] can be introduced as a possible next-generation therapy because of either their intrinsi...