نتایج جستجو برای: polygenic dyslipidemia
تعداد نتایج: 16254 فیلتر نتایج به سال:
CONTEXT Anxiety disorders are common, with a lifetime prevalence of 20% in the U.S., and are responsible for substantial burdens of disability, missed work days and health care utilization. To date, no causal genetic variants have been identified for anxiety, anxiety disorders, or related traits. OBJECTIVE To investigate whether a phobic anxiety symptom score was associated with 3 alternative...
BACKGROUND AND PURPOSE Epidemiological studies show strong associations between kidney dysfunction and risk of ischemic stroke (IS), the mechanisms of which are incompletely understood. We investigated whether these associations may reflect shared heritability because of a common polygenic basis and whether this differed for IS subtypes. METHODS Polygenic models were derived using genome-wide...
Diabetic dyslipidemia is characterized by elevated fasting and postprandial triglycerides, low HDL-cholesterol, elevated LDL-cholesterol and the predominance of small dense LDL particles. These lipid changes represent the major link between diabetes and the increased cardiovascular risk of diabetic patients. The underlying pathophysiology is only partially understood. Alterations of insulin sen...
Alopecia areata (AA) is a multifactorial disorder, in which genetic and environmental factors combine to result in the phenotype (Green and Sinclair, 2000). The prognosis of AA is unpredictable and there is no definitive treatment. Several lines of evidence support the polygenic inheritance of AA, including the high prevalence of the trait, the Gaussian curve of distribution of the phenotype, a...
Liking and respect are postulated as two dimensions of interpersonal attitudes. Liking-disliking is an idiosyncratic response which depends mostly on how target persons influence interests and well-being of the attitude holder and is accompanied by beliefs in their communal traits. Respect-disrespect is a socially shared response which depends mostly on the social status of target persons and i...
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