Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder of young women with long-term metabolic risk and prevalence among pre-marital Sri Lankan 6.3%. Inheritance PCOS likely to be oilgogenic; genetic basis remaining largely unknown in view complex pathophysiology. The genetics expression requires an in-depth study, particularly who have a greater from early age. emergence unanimou...

Background: Having low-grade chronic inflammation state symptoms such as elevated C-reactive protein and interleukin-6 play a crucial role in polycystic ovary syndrome (PCOS). Green tea has antiinflammatory properties. This research evaluates the effect of green tea on inflammatory indexes. Adult Wistar rats were exposed to subcutaneous administration of estradiol valerate for PCOS induction. P...

the relationship between leptin, adiponectin, ghrelin, homocysteine, insulin resistance and other biochemical factors in women with polycystic ovary syndrome (pcos) is controversial. we review how the expanded role of these factors in reproduction might impact our understanding of pcos. for purposes of our review, we accessed the pubmed database during the past 10 years. our review confirms tha...

Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain unknown, mechanism-based treatments are not feasible and current management relies on treatment of symptoms. Hyperandrogenism is the most consistent PCOS characteristic; however, it is unclear whether androgen excess, which is treat...

BACKGROUND Polycystic ovary syndrome (PCOS), a common endocrine disorder, is associated with infertility, menstrual dysfunction, hirsutism and frequent miscarriages. Insulin resistance, as a major cause of PCOS, represents a disorder with increase in inflammatory markers and risk of type 2 diabetes. We aimed to investigate whether inflammatory markers, including C-reactive protein and C3 (Compl...

objective: : polycystic ovary syndrome (pcos) is one of the most common hormonal disorders that can lead to irregular menstrual cycles and hyperandrogenism. reduced levels of progesterone and increased estrogen in these women can perpetually stimulate the endometrial tissue of the uterus. in this study, the effect of pcos induction was studied using estradiol valerate. materials and methods: ad...

Obesity in polycystic ovary syndrome (PCOS) patients poses a significant clinical problem not only due to their fertility issues, but also because of the co-existence of metabolic disorders and their long term health consequences. Obesity leads to increased morbidity, impairs Quality of Life (QoL) and might be the cause of early mortality. Polycystic Ovary Syndrome is one of the most frequent e...

OBJECTIVE The aim of this study was to evaluate the influence of polycystic ovary syndrome (PCOS) and obesity on circulating markers of low-grade inflammation-tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6) and high sensitive C-reactive protein (hsCRP)-in young women without major cardiovascular (CV) risk factors (diabetes, dyslipidemia and arterial hypertension). DESIGN Twenty-five...

Polycystic ovary syndrome (PCOS) is found in 3 to 6% of women in child-bearing age. At the same time PCOS is the most common cause of infertility. The diagnostic criteria for PCOS include: anovulation or ovulatory disorders, hyperandrogenism and typical polycystic ovary image in ultrasound examination in the absence of other causes of hyperandrogenism. The etiology of the syndrome remains unkno...

OBJECTIVE To compare steroid concentrations and steroid product-to-precursor ratios in ovarian follicular fluid (FF) from women with polycystic ovary syndrome (PCOS) and from regularly menstruating women in their early follicular phase, using liquid chromatography-tandem mass spectrometry (LC-MS/MS). Polycystic ovary syndrome involves abnormal regulation of the steroidogenic enzymes, leading to...