Liver X receptors (LXR) alpha and beta play an important role in regulating the expression of genes involved in hepatic bile and fatty acid synthesis, glucose metabolism, as well as sterol efflux. Studies with human embryonic kidney 293 cells indicate that unsaturated fatty acids interfere with oxysterols binding to LXR and antagonize oxysterol-induced LXRalpha activity. In this report, we eval...

BACKGROUND The effect of dietary fats on human health and disease are likely mediated by changes in gene expression. Several transcription factors have been shown to respond to fatty acids, including SREBP-1c, NF-kappaB, RXRs, LXRs, FXR, HNF4alpha, and PPARs. However, it is unclear to what extent these transcription factors play a role in gene regulation by dietary fatty acids in vivo. METHOD...

In this study, we investigated the relationship between unsaturated fatty acids influencing beef flavor and four types of SNPs (c.280A>G, c.388G>A, c.408G>C and c.456A>G) located at exon 2, 3 and 4 of the FABP4 gene, which is a fatty acid binding protein 4 in Korean cattle (n = 513). When analyzing the relationship between single genotype, fatty acids and carcass trait, individuals of GG, GG, C...

Drcarboxylic aciduria is a condition sometimes encountered during routine urine screening for inborn errors of metabolism [l] and may be due to ketosrs, a transient condition m some neonates [2] or a number of enzyme deficiencies mainly involving fatty acid metabolism or transport. Unsaturated dicarboxylic acids have also been reported m some of these conditions. These compounds are usually det...

The aim of the present study was to determine and compare the seasonal changes in the proximate composition, fatty acids profile and fat soluble vitamins content in spring and autumn goby (Neogobius melanostomus) caught from the Bulgarian Black Sea waters. The proximate composition (moisture, protein and total lipid) has been determined according to AOAC (1990).  Analysis of fatty acid methyl e...

lipids play an important role in maintaining human health. thermal process cause to changes in nutritional value as well as changes in the profile of fatty acids in fish. the aim of this study was to evaluate the effect of frying on chemical composition and profile of fatty acids is fish shaary. for doing this project, 10 kg of the fish were purchased from the market of behbahan and with ice we...

Recent physical studies on the lipids of biological membranes have emphasized the potential instability of the lamellar phase of mixtures of lipids containing unsaturated species of phosphatidylethanolamine, plasmenylethanolamine, or monoglycosyldiacylglycerols, all of which are important constituents of the membranes of different groups of prokaryotes. The polar lipid compositions of bacteria ...

Oxygen, a key nutrient in alcoholic fermentation, is rapidly depleted during this process. Several pathways of oxygen utilization have been reported in the yeast Saccharomyces cerevisiae during alcoholic fermentation, namely synthesis of unsaturated fatty acid, sterols and heme, and the mitochondrial electron transport chain. However, the interaction between these pathways has not been investig...

Duchenne muscular dystrophy (DMD) arises as a consequence of mutations in the dystrophin gene. Dystrophin is a membrane-spanning protein that connects the cytoskeleton and the basal lamina. The most distinctive features of DMD are a progressive muscular dystrophy, a myofiber degeneration with fibrosis and metabolic alterations such as fatty infiltration, however, little is known on lipid metabo...

BACKGROUND AND AIM Fatty acids acutely stimulate GLP-1 secretion from L-cells in vivo. However, a high fat diet has been shown to reduce the density of L-cells in the mouse intestine and a positive correlation has been indicated between L-cell number and GLP-1 secretion. Thus, the mechanism of fatty acid-stimulated GLP-1 secretion, potential effects of long-term exposure to elevated levels of d...