OBJECTIVE This study examined the effects of modafinil on apathetic symptomatology, performance of activities of daily living (ADLs), and caregiver burden in individuals with Alzheimer's disease (AD). METHOD 23 participants with a diagnosis of mild-to-moderate probable AD according to National Institute of Neurologic and Communicative Disorder and Stroke-Alzheimer's Disease and Related Disord...

INTRODUCTION Results from studies on awareness disorders in Alzheimer's disease (AD) are controversial because the methodologies, the "objects" of awareness, and the patients' pathologic stage all vary. Our study aimed to compare scores and correlates of awareness according to the stage of the disease and the assessment method. METHODS We compared 20 mild AD patients to 20 mild cognitive impa...

OBJECTIVE The authors report findings from a study of 5,092 community residents who constituted 90% of the elderly resident population of Cache County, Utah. METHOD The 5,092 participants, who were 65 years old or older, were screened for dementia. Based on the results of this screen, 1,002 participants (329 with dementia and 673 without dementia) underwent comprehensive neuropsychiatric exam...

BACKGROUND Apathy is a disturbance of motivation, frequent in survivors of stroke. Several studies have evaluated the rate of apathy secondary to stroke and risk factors. Different conclusions and contradictory findings have been published. We aimed to perform a systematic review and meta-analysis of all studies evaluating apathy secondary to stroke to better estimate its rate and risk factors,...

Abstract This article sheds fresh light on popular attitudes towards politics in the 1940s. It does so by reading against grain of archived material from Mass-Observation’s (M-O) study 1945 General Election, as it played out constituency Fulham East. Where formal reports this investigation have underpinned influential accounts ‘apathy’ 1945, returns to original field notes investigation. By att...

"Mediated terrorism in the 21st century." Behavioral Sciences of Terrorism and Political Aggression, ahead-of-print(ahead-of-print), pp. 1–2

OBJECTIVE We sought to identify apathy metabolic bases in Parkinson disease (PD). METHODS A total of 45 patients with PD who were not clinically depressed (Montgomery-Åsberg Depression Rating Scale [MADRS] <21) and had no dementia (Mattis Dementia Rating Scale [MDRS] >130) were assessed with the Apathy Evaluation Scale (AES) and underwent a resting-state F-18 fluorodeoxyglucose PET (FDG-PET) ...

BACKGROUND Low testosterone in men with Parkinson's disease may be associated with non-motor symptoms of the disease, such as apathy. OBJECTIVE To determine the association between free serum testosterone level and apathy in elderly men with Parkinson's disease. METHODS Consecutive non-demented patients (n = 49) and knowledgeable informants (n = 40) participated in the study. Patients and i...