881 Immune response of neonates to oral poliomyelitis vaccine In the conventional schedule of immunisation infants are given three doses of oral poliomyelitis vaccine starting at, or after, 6 to 8 weeks of age. In the new pulse immunisation strategy three doses of oral poliomyelitis vaccine are given in annual cycles to children under 24 months of age.' I carried out a study to see whether a lo...

World Health Organisation and public health authority records show that 175 cases of paralytic poliomyelitis were imported to industrialised countries between 1975 and 1984. Detailed case reports were therefore analysed to identify characteristic features associated with acquisition of the infection. Of the 175 cases, 96 (55%) were diagnosed in foreign workers or their families, 47 (27%) in nat...

The rate of anaerobic glycolysis of brain tissue was compared for normal animals and animals with experimentally induced poliomyelitis, using two different strains of mice and two different procedures. The report of interference of poliomyelitis with anaerobic glycolysis of brain was not confirmed. In one series there was a small increase and in the other series a small decrease in the brain Q(...

A culture of HeLa cells has been subjected to prolonged observation with the finding that periodically Type III poliomyelitis virus could be isolated from it. A requirement of the culture for survival was the presence in it of serum of certain individuals who had had previous experience with poliomyelitis virus. In the presence of serum containing no antibodies to poliomyelitis virus, the cultu...

continued, page 3 There are large numbers of polio survivors today who contracted acute paralytic poliomyelitis prior to the advent of widespread vaccination programs against poliovirus (PV). What is underappreciated is the fact that polio survivors are many years later at risk of developing new neurological deterioration, a condition recognized in the late ’80s as post-poliomyelitis syndrome (...

We have searched, using a sensitive nested-PCR, for enterovirus RNA in cerebrospinal fluid and post mortem central nervous system (CNS) tissue from patients with previous poliomyelitis with or without late functional deterioration, patients with motor neuron disease (MND), and control patients with other neurological disease or without neurological disease. Enterovirus RNA was detected in patie...

Neuropathogenicity of poliovirus can be attenuated by mutations in the internal ribosomal entry site (IRES) within the 5' nontranslated region of its genome. The Sabin vaccine strains used in prevention of poliomyelitis carry such mutations in their IRES elements. In addition, mutations within the structural and nonstructural proteins of Sabin strains may equally contribute to the attenuation p...