The tetramolecular PNA quadruplex motif has been probed using a dynamic covalent chemistry (DCC) approach to create and characterize a bimolecular PNA quadruplex.

Peptide Nucleic Acid (PNA) is a powerful new biomolecular tool with a wide range of important applications. PNA mimics the behaviour of DNA and binds complementary nucleic acid strands. The unique chemical, physical and biological properties of PNA have been exploited to produce powerful biomolecular tools, antisense and antigene agents, molecular probes and biosensors.

Peptide Nucleic Acids (PNAs) are synthetic mimics of DNA in which the sugar-phosphate backbone has been replaced by a pseudopeptide skeleton. These molecules bind to complementary DNA and RNA sequences with high affinity and specificity, forming complexes with extraordinary chemical and biological stability. First described in 1991, PNAs have received great attention due to their several favora...

Background: Neonates with Perinatal Asphyxia (PNA) are at higher risk for developing Acute Kidney Injury (AKI). Conventionally, Serum Creatinine (SCr) is used to diagnose AKI but lacks specificity during the first few days of life. Neutrophil Gelatinase-Associated Lipocalin (NGAL) has emerged as a novel biomarker in such situations, while its value our setting yet be validated. The study aimed ...

Peptide Nucleic Acids (PNAs) are synthetic mimics of DNA in which the sugar-phosphate backbone has been replaced by a pseudopeptide skeleton. These molecules bind to complementary DNA and RNA sequences with high affinity and specificity, forming complexes with extraordinary chemical and biological stability. First described in 1991, PNAs have received great attention due to their several favora...

Site-specific DNA binding molecules offer the potential for genetic manipulation of mammalian cells. Peptide nucleic acids (PNAs) are a DNA mimic in which the purine and pyrimidine bases are attached to a polyamide backbone. PNAs bind with high affinity to single-stranded DNA via Watson-Crick base pairing and can form triple helices via Hoogsteen binding to DNAPNA duplexes. Dimeric bis-PNAs cap...

Definition Peptide nucleic acid (PNA) is an artificial mimic of nucleic acid, which was invented more than a decade ago (7). The molecule combines many features that are similar to those of natural nucleic acids with characteristics that are rather different or even unique to PNA. First and foremost, N-(2-aminoethyl)-glycine units linked by ▶amide bonds substitute the (deoxy)ribosephosphate bac...

A peptide nucleic acid (PNA) antisense for the AUG translation initiation region of prepro-oxytocin mRNA was synthesized and coupled to a r etro-inverso peptide that is rapidly taken up by cells. This bioconjugate was internalized by cultured cerebral cortex neurons within minutes, according to the specific property of the vector peptide. The PNA alone also entered the cells, but more slowly. C...

The fluorescence lifetimes of parinaric acid (PnA) isomers have been measured in pure solvents and in synthetic phospholipid membranes over a wide temperature range. In pure solvents, dodecane, ethanol, and cyclohexanol, the emission is well described by three exponential components of approximately 40, 12, and 2 ns. The preexponential factor of the long-lifetime component is quite small, and t...

Peptide Nucleic Acids (PNAs) are single-stranded synthetic nucleic acids with a pseudopeptide backbone in lieu of the phosphodiester linked sugar and phosphate found in traditional oligos. PNA designed complementary to the bacterial Shine-Dalgarno or start codon regions of mRNA disrupts translation resulting in the transient reduction in protein expression. This study examines the use of PNA te...