نتایج جستجو برای: plga particles
تعداد نتایج: 159640 فیلتر نتایج به سال:
سنتز پلیمرهای کوئوردیناسیونی جدید از لیگاندهای 2-آمینو نیکوتینیک اسید، 2-کینولین کربوکسیلیک اسید، 2-پیرازین کربوکسیلیک اسید در ابعاد توده، با روش گرایان دمایی و با استفاده از شاخه ی جانبی انجام شده است، این پلیمرها توسط روش طیف سنجی ir شناسایی و پایداری گرمایی آن ها توسط تجزیه های وزن سنجی حرارتی (tga) و تجزیه ی گرمایی تفاضلی (dta) بررسی شده است. در ادامه، ساختار این ترکیبات توسط بلورنگاری پرتو...
Purpose Poly(lactic-co-glycolic) acid (PLGA) inserts have been successfully developed for the treatment of posterior eye disease as a means of reducing injection frequency of intravitreally administered therapeutics. PLGA microspheres are also of interest for the delivery of intravitreal drugs, since they offer the advantage of being easily injected without surgical procedures or large injector...
Conjugation of polyamidoamine dendrimers on biodegradable microparticles for nonviral gene delivery.
We report on the preparation and characterization of poly(D, L-lactide-co-glycolide) (PLGA) microparticles with surface-conjugated polyamidoamine (PAMAM) dendrimers of varying generations. The buffering capacity and zeta-potential of the PLGA PAMAM microparticles increased with increasing generation level of the PAMAM dendrimer conjugated. Conjugation of the PAMAM dendrimer to the surface of th...
Efficient delivery of antigens through oral immunization is a first and critical step for successful induction of mucosal immunity, which can provide protection against pathogens invading the mucosa. Membranous/microfold cells (M cells) within the mucosa can transcytose internalized antigen without degradation and thus play an important role in initiating antigen-specific mucosal immune respons...
Background and Objective: Poly D,L-lactic-co-glycolic acid (PLGA) is known as biodegradable and biocompatible polymer. These polymers have recently received much attention in tissue engineering. The aim of this study was to investigate the biological behavior of the bone marrow stromal cells (BMSCs) in culturing with PLGA nanofibers coated with poly-L-lysine or gelatin. Materials and Methods: I...
We report, for the first time, on the preparation, characterization and in vitro testing of poly(D,L-lactide-co-glycolide) (PLGA) microparticles loaded with polyamidoamine (PAMAM)-plasmid DNA (pDNA) dendriplexes. Loading of pDNA into the PLGA microparticles increased by 150% when pDNA was first complexed with PAMAM dendrimers relative to loading of pDNA alone. Scanning electron microscopy (SEM)...
Abstract Contrast Induced Nephropathy is the most severe side-effect arising after non-ionic iodinated contrast agents (CAs) intravenous administration. The use of antioxidants (i.e., N-Acetylcysteine; NAC) one attempted prevention approaches. Herein, we describe microfluidic-assisted synthesis polymeric nanoparticles (NPs) as new multifunctional blood pool CA. aim this research to co-encapsula...
نانوالیاف پلیمری تولید شده به روش الکتروریسی در سال های اخیر کاربرد بسیاری در مهندسی بافت و توسعه سامانه های رهایش دارو پیدا کرده اند. یکی از پلیمرهای مورد توجه در این زمینه، پلی لاکتیک گلایکولیک اسید (plga) است. این پلیمر به علت زیست سازگاری و زیست تخریب پذیری، گزینه مناسبی برای ساخت داربست های مورد استفاده در کشت سلولی می باشد. plga دارای خواص سطحی مطلوبی برای چسبیدن سلول ها به آن نیست، به هم...
Nanoparticles of S-ibuprofen: Physicochemical Characterization, Release Profile and Ocular Tolerance
Extended Abstract Ocular drug delivery systems have the potential to improve drug bioavailability, reducing side effects and facilitating patient adherence by avoiding frequent administration, which is a major noncompliance with many chronic eye disorders as inflammatory process. Several recent studies have shown that nonsteroidal anti-inflammatory drugs are also effective in the treatment or p...
Immune-modifying particles (IMPs) composed of biodegradable poly(lactic-co-glycolic acid) (PLGA-IMP) are taken up by circulating inflammatory monocytes via scavenger receptor MARCO and lead them to traffic the spleen where they undergo apoptosis. PLGA-IMPs has been demonstrated improve immune-mediated pathology in diverse tissues conditions. Here we report using intravenous for severe acute ski...
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