UNLABELLED BACKGROUND.: Microvascular free tissue transfer has become increasingly popular in the reconstruction of head and neck defects, but it also has its disadvantages. Tissue engineering allows the generation of neo-tissue for implantation, but these tissues are often avascular. We propose to combine tissue-engineering techniques together with flap prefabrication techniques to generate a ...

A microsphere composite made of poly(DL-lactic-co-glycolic acid) (PLGA), mesoporous silica nanoparticle (MSN), and nanohydroxyapatite (nHA) (PLGA-MSN/nHA) was prepared and evaluated as bone tissue engineering materials. The objective of this study was to investigate the synergistic effect of MSN/nHA on biocompatibility as well as its potential ability for bone formation. First, we found that th...

Drug resistance has become a main obstacle for the effective treatment of lung cancer. To address this problem, a novel biocompatible nanoscale package, poly(d,l-lactide-co-glycolide)-Tween 80, was designed and synthesized to overcome paclitaxel (PTX) resistance in a PTX-resistant human lung cancer cell line. The poly(d,l-lactide-co-glycolide) (PLGA)-Tween 80 nanoparticles (NPs) could efficient...

BACKGROUND Squamous cell carcinoma (SCC) is a common skin cancer, and its treatment is still difficult. The aim of this study was to evaluate the effectiveness of nanoparticle (NP)-assisted 5-aminolevulinic acid (ALA) delivery for topical photodynamic therapy (PDT) of cutaneous SCC. MATERIALS AND METHODS Ultraviolet-induced cutaneous SCCs were established in hairless mice. ALA-loaded polylact...

PEG-PLGA nanoparticles (NPs) modified with anti-CD133 and tumor-targeting single-chain antibody fragment (scFV-NPs) for systemic delivery of methioninase (METase) and pemetrexed for gastric carcinoma were successfully formulated. The structure characterization and biological functions of METase-pemetrexed-loaded scFV-PEG-PLGA NPs (scFV-METase/pemetrexed-NPs) in vitro were investigated. Function...

Resveratrol (RSV) has been shown to effectively suppress chronic rhinosinusitis with nasal polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively rapid clearance from the administration site. To address this limitation, we propose mucoadhesive nanostructured micropar...

FABRICATION OF TWO-DIMENSIONAL NANOSTRUCTURES ON GLASS USING NANOSPHERE LITHOGRAPHY by

Nanobiomaterials (NBMs) are currently being tested in numerous biomedical applications, and their use is expected to grow rapidly the near future. Many different types of nanomaterials employed for a wide variety applications. Silver nanoparticles (nano-Ag) have been investigated antibacterial, antifungal, osteoinductive properties be used catheters, wound healing, dental bone healing. Polymeri...

With the great success of graphene in biomedical field, carbon nanotubes have attracted increasing attention for different applications ophthalmology. Here, we report a novel retinal sheet composed (CNTs) and poly(lactic-co-glycolic acid) (PLGA) that can enhance cell therapy. By tuning our CNTs to regulate mechanical characteristics retina sheets, were able improve vitro viability ganglion cell...

BACKGROUND Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (-) Poisson's ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell. METHODS Organic/inorganic composite scaffolds were prepared by mixing hydroxyapatite (HA) to poly(lactide-co-glycolide) (PLGA). To induce NPR in composite scaffold, 3-directional volumetri...