Elevations in the intracellular Ca(2+) concentration activate the serine/threonine protein kinase Ca(2+)/calmodulin-dependent protein kinase II (CaM kinase II). We tested the hypothesis that increased sarco(endo)plasmic reticulum Ca(2+)-ATPase activity by phospholamban (PLB) phosphorylation contributes to smooth muscle relaxation by elevating the sarcoplasmic reticulum (SR) Ca(2+) load and incr...

The small G protein Ras-mediated signaling pathway has been implicated in the development of hypertrophy and diastolic dysfunction in the heart. Earlier cellular studies have suggested that the Ras pathway is responsible for reduced L-type calcium channel current and sarcoplasmic reticulum (SR) calcium uptake associated with sarcomere disorganization in neonatal cardiomyocytes. In the present s...

Countable projective limits of countable inductive limits, so-called PLB-spaces, of weighted Banach spaces of continuous functions have recently been investigated by Agethen, Bierstedt and Bonet, who analyzed locally convex properties in terms of the defining double sequence of weights. We complement their results by considering a defining sequence which is the product of two single sequences. ...

Effective detection of potato late blight (PLB) is an essential aspect cultivation. However, it a challenge to detect in asymptomatic biotrophic phase fields with conventional imaging approaches because the lack visual symptoms canopy. Hyperspectral can capture spectral signals from wide range wavelengths also outside wavelengths. Here, we propose deep learning classification architecture for h...

Studies on groundwater have traditionally been based declining levels and associated ecological, environmental, geological problems. However, due to extreme hydrometeorological events human activities, rising observed in many areas. The daily from 2018 2020 for the Poyang Lake Basin (PLB) Jiangxi Province were recorded. statistical characteristics of abnormal level (AGLR) factors influencing dy...

Introduction Primary lymphoma of the bone (PLB) is uncommon clinical entity with the vast majority of the cases are non-Hodgkin's lymphoma. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of PLB. Case Report We report a case of 60-year-old female presented with pain in the right hip that persisted for 2 months. Plain X-ray, computed tomography, and magnetic resonance imaging ...

Primary lymphoma of the bone (PLB) primarily arising from the medullary cavity is an extremely rare entity, with only retrospective studies and sporadic cases reported in the literature. The current study presents one case of PLB treated with chemotherapy and radiotherapy, and a review of the literature to elucidate the optimal treatment of PLB. A 73-year-old female presented with pain in the l...

We have studied the effects of C28R2, a basic peptide derived from the autoinhibitory domain of the plasma membrane Ca-ATPase, on enzyme activity, oligomeric state, and E1-E2 conformational equilibrium of the Ca-ATPase from skeletal and cardiac sarcoplasmic reticulum (SR). Time-resolved phosphorescence anisotropy (TPA) was used to determine changes in the distribution of Ca-ATPase among its dif...

BACKGROUND To determine the influence of breathing maneuver and sitting posture on tidal volume (TV), respiratory rate (RR), and muscle activity of the inspiratory accessory muscles in patients with chronic obstructive pulmonary disease (COPD). METHODS Twelve men with COPD participated in the study. Inductive respiratory plethysmography and surface electromyography were used to simultaneously...

Phospholamban (PLB) is a pentameric protein that plays an important role in regulating cardiac contractility via a reversible inhibitory association with the sarcoplasmic reticulum Ca2+ATPase (SERCA), the enzyme responsible for maintaining correct calcium homeostasis. Here we study the functional and biophysical characteristics of a PLB mutant associated with human dilated cardiomyopathy (DCM),...