Abstract Purpose of Review To review the role platelet transfusion in resuscitation for trauma, including normal function and alterations behavior following blood product ratios impact on function, assays, risks considerations storage, potential adjunct therapies synthetic platelets. Recent Findings Platelets are a critical component clot formation breakdown injury, addition to these hemostatic...

Adenine and guanine nucleotide metabolism of platelet concentrates (PCs) was studied during storage for transfusion at 22 f 2°C over a 7-day period using high-pressure liquid chromatography. There was a steady decrease in platelet adenosine triphosphate (ATP) and adenosine diphosphate (ADP), which was balanced quantitatively by an increase in plasma hypoxanthine. As expected, ammonia accumulate...

INTRODUCTION Uterine atony is the most common cause of primary post partum haemorrhage. We report a case where this was complicated by two rare conditions, platelet storage pool disease and placenta diffusa. Platelet storage pool disease is a platelet aggregation disorder associated with mild to moderate bleeding diathesis. There are limited cases reported in pregnancy. Placenta diffusa is a ra...

General Considerations D espite the essential role of platelets in arterial thrombogenesis, personalized antiplatelet therapy based on platelet function tests (PFTs) did not improve clinical outcome after coronary revascularization and did not predict recurrent ischemic or bleeding events in individual patients. To understand why these point-of-care PFTs have yielded so little clinical benefit,...

General Considerations D espite the essential role of platelets in arterial thrombogenesis, personalized antiplatelet therapy based on platelet function tests (PFTs) did not improve clinical outcome after coronary revascularization and did not predict recurrent ischemic or bleeding events in individual patients. To understand why these point-of-care PFTs have yielded so little clinical benefit,...

BACKGROUND AND OBJECTIVES   Patients with anaphylactic transfusion reactions require washed platelet concentrates (PCs) for subsequent platelet (PLT) transfusions. New PLT additive solutions (PASs) contain substances that might be beneficial for the preservation of PLT function during storage. This study compares the quality of PLTs washed and stored with T-Sol, Composol or SSP+. STUDY DESIGN...

The antiestrogenic drug tamoxifen, used in patients with breast cancer, is associated with an increase in arterial and venous thrombotic events, the mechanism of which is not clearly understood. We report a case of a lady who presented with new bruising and prolonged bleeding following a tooth extraction 4-6 weeks after starting tamoxifen. Investigations were consistent with an acquired platele...

An 11-year-old American boy was staying with his family in Indonesia. He presented with a 5-month history of recurrent bruises and ecchymosis. A clinical diagnosis of acquired platelet dysfunction with eosinophilia was made when his full blood counts showed hypereosinophilia (7.4×10(9)/L) with normal platelet count and gray platelets under the microscope. The diagnosis was supported by abnormal...