It has been proposed for several decades that infections may be responsible for the accelerated development of atherosclerosis. The initiation of the atherosclerotic plaque is ascribed to focal accumulation of lipids. This explains the importance of plasma lipids in the development of atherosclerosis. Recent reports point towards a possible association between periodontal disease and increased ...

introduction: the importance of screening for diabetes mellitus is a contruversial issue worldwide, its vitality is obvious when it leads to effective treatment for those identified at screening. this study was performed in isfahan city to evaluate quality of care and treatment one year after diagnosis, in diabetic patients, newly diagnosed by screening. materials and methods : in this prospect...

Lipids and Their Functions in Human Physiology.-Plasma lipoproteins transport the biologically important lipid compounds: triglycerides, phospholipids, cholesterol, and cholesteryl esters. Insight into the function of plasma lipoproteins may be obtained, in part, from available information on the physiologic functions of these major classes of lipids. Briefly these functions include the followi...

Neonatal hypoxia increases aldosterone production and plasma lipids. Because fatty acids can inhibit aldosterone synthesis, we hypothesized that increases in plasma lipids restrain aldosteronogenesis in the hypoxic neonate. We exposed rats to 7 days of hypoxia from birth to 7 days of age (suckling) or from 28 to 35 days of age (weaned at day 21). Plasma was analyzed for lipid content, and stero...

An ultraperformance LC (UPLC) method for the separation of different lipid molecular species and lipid isomers using a stationary phase incorporating charged surface hybrid (CSH) technology is described. The resulting enhanced separation possibilities of the method are demonstrated using standards and human plasma extracts. Lipids were extracted from human plasma samples with the Bligh and Dyer...

The relative roles of circulatory glucose, muscle glycogen, and lipids in shivering thermogenesis are unclear. Using a combination of indirect calorimetry and stable isotope methodology ([U-13C]glucose ingestion), we have quantified the oxidation rates of these substrates in men acutely exposed to cold for 2 h (liquid conditioned suit perfused with 10 degrees C water). Cold exposure stimulated ...

Liver damage and alterations in the exocrine function of the gland lead to a profound alteration of the plasma lipoprotein profile. To determine whether hepatic disease results in changes in the lipoprotein fatty acid composition, i.e. to determine whether liver function influences the homeostasis of complex lipids in plasma, we studied the fatty acid profile of lipids from VLDL, LDL and HDL, a...

Our understanding of membranes and membrane lipid function has lagged far behind that of nucleic acids and proteins, largely because it is difficult to manipulate cellular membrane lipid composition. To help solve this problem, we show that methyl-α-cyclodextrin (MαCD)-catalyzed lipid exchange can be used to maximally replace the sphingolipids and phospholipids in the outer leaflet of the plasm...