نتایج جستجو برای: plasma concentration of insulin

تعداد نتایج: 21231010  

Journal: :Archives of disease in childhood 1993
J M Hawdon A Aynsley-Green K G Alberti M P Ward Platt

The glucoregulatory role of insulin in adult subjects is undisputed. However, less is known about the secretion of insulin and its actions in the neonatal period, either for healthy subjects, or for those at risk of disordered blood glucose homoeostasis. The relationships between blood glucose and plasma immunoreactive insulin concentrations were therefore examined in 52 healthy children (aged ...

Journal: :The Journal of biological chemistry 2005
Hiroshi Iwakura Kiminori Hosoda Choel Son Junji Fujikura Tsutomu Tomita Michio Noguchi Hiroyuki Ariyasu Kazuhiko Takaya Hiroaki Masuzaki Yoshihiro Ogawa Tatsuya Hayashi Gen Inoue Takashi Akamizu Hiroshi Hosoda Masayasu Kojima Hiroshi Itoh Shinya Toyokuni Kenji Kangawa Kazuwa Nakao

We developed and analyzed two types of transgenic mice: rat insulin II promoter-ghrelin transgenic (RIP-G Tg) and rat glucagon promoter-ghrelin transgenic mice (RGP-G Tg). The pancreatic tissue ghrelin concentration measured by C-terminal radioimmunoassay (RIA) and plasma desacyl ghrelin concentration of RIP-G Tg were about 1000 and 3.4 times higher than those of nontransgenic littermates, resp...

2015
S. Tokumoto Y. Hamamoto K. Fujimoto E. Yamaguchi E. Okamura S. Honjo H. Ikeda Y. Wada A. Hamasaki H. Koshiyama

AIM To investigate the relationship between plasma betatrophin concentrations and insulin secretion capacity in people with Type 2 diabetes. METHODS Glucagon stimulation tests (1 mg) were performed in 70 people with Type 2 diabetes after an overnight fast. Plasma betatrophin concentrations were measured using an enzyme-linked immunosorbent assay. Insulin secretion capacity was evaluated by me...

Journal: :Journal of animal science 1991
H Sano M Nakai T Kondo Y Terashima

Insulin responsiveness to glucose and tissue responsiveness to insulin, using the hyperglycemic clamp and the hyperinsulinemic euglycemic clamp techniques, were measured in lactating, late pregnant, and nonpregnant, nonlactating (NPNL) beef cows. The glucose infusion rate (GIR) in the hyperglycemic clamp technique was higher (P less than .05). in lactating cows than in NPNL cows. The plateau in...

Journal: :The Journal of General Physiology 1961
J. Eichhorn O. Hechter

The effect of insulin administration upon D-xylose-1-C(14) penetration into the diaphragm and gastrocnemius muscles of functionally nephrectomized normal, hypophysectomized, and adrenalectomized rats has been examined. It was found in all groups that after the administration of tracer amounts of D-xylose, this sugar enters the cell water of diaphragm to a greater extent than in gastrocnemius mu...

Journal: :international journal of endocrinology and metabolism 0
ganapathy saravanan department of biochemistry, centre for biological science, k.s.rangasamy college of arts and science, thokkavadi, tiruchengode,tamil nadu, india; research department of biochemistry, centre for biological science, k. s. rangasamy college of arts and science, thokkavadi, tiruchengode, tamil nadu, 637215, india. tel: +91-9843954422 ponnusamy ponmurugan department of biotechnology, k.s.rangasamy college of technology, thokkavadi, tiruchengode, tamil nadu, india

conclusions the results of the present investigation suggest that sac could be used as a food supplement in the treatment of diabetes characterized by provoked antioxidant status, altered blood glucose, and hormones level. results the levels of glucose, cyp2e1 activity, thiobarbituric acid reactive substances (tbars), hydroperoxide, and ceruloplasmin were increased significantly; whereas, the l...

Journal: :The Journal of clinical investigation 1998
R E Pratley D B Thompson M Prochazka L Baier D Mott E Ravussin H Sakul M G Ehm D K Burns T Foroud W T Garvey R L Hanson W C Knowler P H Bennett C Bogardus

Type 2 diabetes mellitus is a common chronic disease that is thought to have a substantial genetic basis. Identification of the genes responsible has been hampered by the complex nature of the syndrome. Abnormalities in insulin secretion and insulin action predict the development of type 2 diabetes and are, themselves, highly heritable traits. Since fewer genes may contribute to these precursor...

2016
David C Polidori Richard N Bergman Stephanie T Chung Anne E Sumner

Insulin clearance is a highly variable and important factor that affects circulating insulin concentrations. We developed a novel model-based method to estimate both hepatic and extrahepatic insulin clearance using plasma insulin and C-peptide profiles obtained from the insulin-modified frequently sampled intravenous glucose tolerance test. Data from 100 African immigrants without diabetes (mea...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 1998
Toshi Kinouchi Kyoko Koizumi Tamotsu Kuwata Takaji Yajima

The development of pancreatic amylase activity was examined in rats fed in regular cages or in special cages, designed so the pups could not reach solid food to prevent weaning. In both groups, the amylase activity in zymogen granules increased in rat pups aged 14 days, peaked at 18 days, and thereafter remained at a 1.6-fold higher level than at 14 days of age. An increase in the plasma concen...

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