To investigate the effects of treatment with Myo-inositol (an insulin sensitizing drug), on circulating insulin, glucose tolerance, ovulation and serum androgens concentrations in women with the Polycystic Ovary Syndrome (PCOS). Forty-two women with PCOS were treated in a double-blind trial with Myo-inositol plus folic acid or folic acid alone as placebo. In the group treated with Myo-inositol ...

Background Guselkumab was efficacious in reducing signs and symptoms of psoriatic arthritis the phase 3 DISCOVER-1 DISCOVER-2 studies. We aimed to evaluate efficacy guselkumab post-hoc analyses patients with imaging-confirmed sacroiliitis consistent axial involvement. Methods In DISCOVER-1, 381 active (defined as ?3 swollen joints, tender C-reactive protein [CRP] ?0·3 mg/dL) DISCOVER-2, 739 ?5 ...

OBJECTIVE To investigate the efficacy and safety of liraglutide added to capped insulin doses in subjects with type 1 diabetes. RESEARCH DESIGN AND METHODS A 26-week, placebo-controlled, double-blind, parallel-group trial enrolling 835 subjects randomized 3:1 receiving once-daily subcutaneous liraglutide (1.8, 1.2, and 0.6 mg) or placebo added to an individually capped total daily dose of ins...

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Accurate quantification of gluconeogenic flux following alcohol ingestion in overnight-fasted humans has yet to be reported. [2-13C1]glycerol, [U-13C6]glucose, [1-2H1]galactose, and acetaminophen were infused in normal men before and after the consumption of 48 g alcohol or a placebo to quantify gluconeogenesis, glycogenolysis, hepatic glucose production, and intrahepatic gluconeogenic precurso...

OBJECTIVES This 24-week, multicenter, double-blind, randomized, placebo-controlled study (NCT00791999) compared efficacy and safety of certolizumab pegol (CZP) in combination with methotrexate (MTX) vs placebo plus MTX in Japanese rheumatoid arthritis (RA) patients with inadequate response to MTX. METHODS In total, 316 patients were randomized 1:1:1:1 to subcutaneous CZP 100, 200, or 400 mg (...

BACKGROUND Insomnia disorder is defined as a combination of dissatisfaction with sleep quantity or quality and a significant negative impact on daytime functioning. Chronic insomnia disorder refers to clinical symptoms of persistent insomnia at least three nights a week for at least 3 months. Prevalence estimates of insomnia disorder range from 12% to 20% in the adult population, with approxima...

Conditioning procedures are used in many placebo studies because evidence suggests that conditioning-related placebo responses are usually more robust than those induced by verbal suggestions alone. However, it has not been shown whether there is a causal relation between the number of conditioning trials and the resistance to extinction of placebo and nocebo responses. Here we test the effects...

Abrocitinib, an oral once-daily Janus kinase 1 selective inhibitor, is being investigated for the treatment of moderate-to-severe atopic dermatitis (AD). This post hoc analysis evaluated if prior with biologic therapy affects response to abrocitinib. Data from patients (pts) with/without previous each arm (abrocitinib 200 mg or 100 mg, placebo) phase 2b (NCT02780167) and 3 JADE MONO-1 (NCT03349...

Apremilast, an oral, small-molecule phosphodiesterase 4 inhibitor, works intracellularly within immune cells to regulate inflammatory mediators. This phase 2b randomized, placebo-controlled study evaluated efficacy and safety of apremilast among Japanese patients with moderate to severe plaque psoriasis. In total, 254 patients were randomized to placebo, apremilast 20 mg b.i.d. (apremilast 20) ...