The cation binding characteristics of the mutant E327A formed in the sheep al isoform of the Na+,K+-ATPase were examined using [3H]ouabain binding as a function of monovalent cation concentrations. Equilibrium competition binding assays in the presence of Mg2+, inorganic phosphate and various amounts of unlabelled ouabain indicated that both wild-type sheep al protein and the E327A mutant expre...

Methods This retrospective observational study is conducted in intensive care unit of combined military hospital Peshawar. Total of 2041 patients are included in this study during a period from 2011 to 2014. Only those patients were included in the study who were 12 years or older, those who require organ support and had ICU stay for at least 24 hours . Patients with advanced disease who requir...

In this Perspective, we discuss some recent developments in the study of the mitochondrial scaffolding protein AKAP121 (also known as AKAP1, or AKAP149 as the human homolog), with an emphasis on its role in mitochondrial physiology. AKAP121 has been identified to function as a key regulatory molecule in several mitochondrial events including oxidative phosphorylation, the control of membrane po...

We define higher Frobenius-Schur indicators for objects in linear pivotal monoidal categories. We prove that they are category invariants, and take values in the cyclotomic integers. We also define a family of natural endomorphisms of the identity endofunctor on a k-linear semisimple rigid monoidal category, which we call the Frobenius-Schur endomorphisms. For a k-linear semisimple pivotal mono...

The joining of the 15-carbon farnesyl group ðC15H25Þ and the 20-carbon geranylgeranyl group ðC20H33Þ to protein–cysteines at or near their carboxy-termini is catalyzed by protein farnesyltransferase (FTase) and protein geranylgeranyltransferase-I and II (GGTase-I and GGTase-II) [1]. The prenyltransferases are heterodimers consisting of aand b-subunits with combined molecular masses ranging from...

A player's influence relative to a mechanism and opponents' strategies is the maximum difference his action can make in the expected value of a collective outcome. A player is :-pivotal if his influence exceeds a threshold :. We provide tight bounds on the number of pivotal players and on average influence. These bounds are uniform over all mechanisms and action profiles and are achieved at mec...