The present study is designed to explore the interactions between HPA axis hormones and the abuse-related effects of cigarette smoking. To assess the temporal relationship between anterior pituitary and adrenal hormones, cardiovascular measures, and the subjective reports were obtained by using Exponential Failure Time Model, Weibull & Gamma Failure Models. AMS Subject Classification: 60 E.

Knockout mice lacking the orphan nuclear receptor steroidogenic factor 1 (SF1) exhibit a complex endocrine phenotype that includes adrenal and gonadal agenesis, impaired expression of pituitary gonadotropins, and absence of the ventromedial hypothalamic nucleus (VMH). These multiple defects complicate efforts to delineate primary versus secondary effects of SF1 deficiency in different tissues, ...

We still do not understand the pathogenesis of the majority of pituitary adenomas or why, once formed, their behaviour tends to be so benign. Understanding trophic activity in the normal pituitary may be the key. Despite the fact that changes in indices of cell division and programmed cell death that are too small to measure can produce highly significant fluxes in cell populations, little by l...

Ghrelin, leptin, and endogenous glucocorticoids play a role in appetite regulation, energy balance, and growth. The present study assessed the effects of dexamethasone (DEX) on these hormones, and on ACTH and pituitary proopiomelanocortin (POMC) and corticotropin-releasing hormone receptor-1 (CRHR1) mRNA expression, during a common metabolic stress - neonatal hypoxia. Newborn rats were raised i...

Nc ORMAL reproduction and lactation in domestic animals are regulated by hormones, a group of chemical materials that are secreted by the ductless or endocrine glands directly into the blood stream. The blood carries these chemical messengers to the parts of the body where they produce their effects. Of the endocrine glands, the pituitary is the most important. In the cow it is about the size o...

Pituitary apoplexy occurs as a very rare complication following pituitary function tests. Signs and symptoms are due to the rapid expansion of an infarcted and/or haemorrhagic pituitary adenoma. We report a case of macroadenoma, in which pituitary apoplexy developed 30 minutes after administration of thyrotropin-releasing hormone (TRH) and gonadotropin-releasing hormone (GnRH) injections. Magne...

in persian traditional medicine is believed that camphor (a crystalline ketone obtained from cinnamomum camphora) is a suppressor of sexual behaviors. this study examined the central effects of camphor on sexual hormones (lh, fsh and testosterone) and gnrh plasma levels in male rat. male wistar rats weighing 250-260gr were selected and divided into control (no treatment), sham (icv injection of...

OBJECTIVE Pituitary tumour transforming gene (PTTG) is a recently identified protooncogene, ubiquitously expressed in pituitary tumours at levels higher than those detected in normal pituitary. Although the precise function of PTTG protein is unknown, in vitro experiments have shown that it induces angiogenesis. In this study, we have examined the potential relationship between the level of PTT...