Pengembangan bentuk sediaan melalui rute topikal sebagai antibakteri sudah banyak dilakukan salah satunya dalam gel. Bentuk ini bisa dimodifikasi penghantaran transdermal dimana obat dapat diaplikasikan dengan aktivitas berupa efek sistemik anti jerawat. Bahan alam yang berpotensi adalah daun sirih hijau (Piper betle L.) karena adanya kandungan senyawa flavonoid menghambat pertumbuhan bakteri p...

Objective: The purpose of this study is to create and assess edible film formulations from betel (Piper betle L.) leaf extract that may be used treat Streptococcus mutans bacteria-caused halitosis.
 Methods: Using ethanol as a solvent, the extraction process was employed produce concentrated leaf. To find minimum dose could suppress bacteria development, antibacterial activity studied on s...

Sepsis is an organ dysfunction caused by dysregulation of immune response towards systemic infection with high incidence and mortality rate. Innovative breakthrough required to manage sepsis especially extended spectrum beta lactamase (ESBL) producing Escherichia coli (E. coli) induced sepsis. Utilization Piper betle extract could be considered as alternative therapy should proven scientificall...

Piper betle (PB) is a traditional medicine that is widely used to treat different diseases around Asian region. The leaf extracts contain various bioactive compounds, which were reported to have antidiabetic, antibacterial, anti-inflammatory, antioxidant, and anticancer effects. In this study, the effect of PB aqueous extracts on replicative senescent human diploid fibroblasts (HDFs) was invest...