The worldwide incidence of melanoma is rising faster than any other cancer, and prognosis for patients with metastatic disease is poor. Current targeted therapies are limited in their durability and/or effect size in certain patient populations due to acquired mechanisms of resistance. Thus, the development of synergistic combinatorial treatment regimens holds great promise to improve patient o...

Whole genome analysis based on next generation sequencing (NGS) now represents an affordable framework in public health systems. Robust analytical pipelines of genomic data provides in short laps of time (hours) information about taxonomy, comparative genomics (pan-genome) and single polymorphisms profiles. Pathogenic organisms of interest can be tracked at the genomic level, allowing monitorin...

structural health monitoring of cracked structures is one of beloved subject of researchers recently. consider of crack behavior in the water and energy pipeline is important because of environmental problems. in this paper consider of crack parameters in the underwater pipe subjected to mechanical transient load is investigated. for this purpose, three- dimensional parametric model of cracked ...

Soil microbiota represent one of the ancient evolutionary origins of antibiotic resistance and have been proposed as a reservoir of resistance genes available for exchange with clinical pathogens. Using a high-throughput functional metagenomic approach in conjunction with a pipeline for the de novo assembly of short-read sequence data from functional selections (termed PARFuMS), we provide evid...

Pipelines carry different types of petroleum products from production areas to long-distance terminals. This paper introduces a novel Mixed Integer Linear Programming (MILP) based on a continuous time representation for scheduling a multi-product pipeline system connecting a unique refinery to several distribution centers where the mid-terminals are able to both inject product into the pipeline...

The modern real-time graphics pipeline is a versatile parallel architecture that accommodates a wide range of rendering techniques. The architecture is implemented by heavily optimized graphics processors (GPUs) that employ a mixture of applicationprogrammable and fixed-function processing resources, yet its design lends itself to a simple programming model easily understood by non-expert progr...

Arguably, the natural gas transmission pipeline infrastructure in Iran represents one of the largest and most complex mechanical systems in the world. The optimization of large gas trunk lines known as IGAT results in reduced fuel consumption or higher capability and improves pipeline operation. In the current study, a single-objective optimization was conducted for Khormoj compressor station o...