Although some symptoms of dermatologic diseases, such as pruritus and pain, can be subjectively assessed only by patients, the most commonly used endpoints in dermatology drug research traditionally have been clinician-reported outcomes. Research has found that patient-reported outcomes (PROs) were included in only one-quarter of 125 trials conducted between 1994 and 2001. Our objective was to ...

Creams and lotions use emulsifiers to create a physically stable vehicle for topically applied dosage forms. The minimum temperature required an anionic emulsifier form micelles, which can cause lipid extraction from skin result in irritation, is known as the Krafft (TK). A cream or lotion formulated with having TK above safe water exposure temperatures (approximately 50°C) cannot irritate due ...

insights from the randomized TAXUS II trial. Circulation 2005;111:900–905. 27. Wieneke H, Dirsch O, Sawitowski T, Gu YL, Brauer H, Dahmen U, Fischer A, Wnendt S, Erbel R. Synergistic effects of a novel nanoporous stent coating and tacrolimus on intima proliferation in rabbits. Catheter Cardiovasc Interv 2003;60: 399–407. 28. Kollum M, Farb A, Schreiber R, Terfera K, Arab A, Geist A, Haberstroh ...