Chin J Cancer Res 2013;25(3):267-268 www.thecjcr.org In the mid 1940s, Robert Wilson (1) hypothesized that a highly localized deposition of energy from a proton beam could be used to increase the radiation dose to tumors while minimizing radiation to adjacent normal tissues. The depthdose distribution of a proton beam differs significantly from that of a photon beam. Protons show increasing ene...

Aeromonas veronii is a pathogenic gram-negative bacterium, which infects a variety of animals and results in mass mortality. The stalled-ribosome rescues are reported to ensure viability and virulence under stress conditions, of which primarily include trans-translation and alternative ribosome-rescue factor A (ArfA) in A. veronii. For identification of specific peptides that interact and inhib...

We present a combined macro-scale/micro-scale computational approach to quantify oxygen transport and flow-mediated shear stress to human chondrocytes cultured in three-dimensional scaffolds in a perfusion bioreactor system. A macro-scale model was developed to assess the influence of the bioreactor design and to identify the proper boundary conditions for the micro-scale model. The micro-scale...

Normal pigmentation depends on the uniform distribution of melanin-containing vesicles, the melanosomes, in the epidermis. Griscelli syndrome (GS) is a rare autosomal recessive disease, characterized by an immune deficiency and a partial albinism that has been ascribed to an abnormal melanosome distribution. GS maps to 15q21 and was first associated with mutations in the myosin-V gene. However,...

s / 87 (2003) 199–308 299 interest. When injured, bone does not heal with a fibrous scar, as do virtually all other tissues. An attractive method of bone repair is to culture bone cells on polymer scaffolds in vitro and subsequently implant these artificial hybrid materials [2]. Interesting polymers for these scaffolds are PEOT/PBT block copolymers. The composition with 70 wt% PEO soft segment ...

BACKGROUND Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic encephalopathic state associated with reversible cerebral vasogenic edema. It is an increasingly recognized occurrence in the oncology population. However, it is very uncommon in patients with primary brain tumors (PBTs). The aim of this study was to analyze the clinicoradiological features and report the clinical ou...

Chediak-Higashi syndrome which appears to be a lysosomal disease (Douglas and Fudenberg, 1969; White, 1966) is characterized by partial albinism, photophobia, recurrent infections, hepatosplenomegaly, and a distinctive leucocyte anomaly (Chediak, 1952; Higashi, 1954). Available genetic and fine structural studies suggest that the condition is inherited as an autosomal recessive trait (Sadan et ...

To the Editor: Neurofibromatosis type 1 (NF1) is an autosomal dominant, neurocutaneous disorder. In most cases, cutaneous pigmentary manifestations are main diagnostic clue. NF1 characterized by hyperpigmentation—café au lait macules (CALMs), skinfold freckling, and melanotic plexiform neurofibromas. However, hypopigmented lesions have received little attention in patients with NF1. Riccardi1Ri...

A mass‐balance model for Lake Superior was applied to polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and mercury to determine the major routes of entry and the major mechanisms of loss from this ecosystem as well as the time required for each contaminant class to approach steady state. A two‐box model (water column, surface sediments) incorporating seasonally adjuste...

Native extracellular matrix (ECM) is a complex fibrous structure loaded with bioactive cues that affects the surrounding cells. A promising strategy to mimicking native tissue architecture for tissue engineering applications is to engineer fibrous scaffolds using electrospinning. By loading appropriate bioactive cues within these fibrous scaffolds, various cellular functions such as cell adhesi...